Namdar Nazli Dizen, Arikan Inci, Kahraman Cuneyt, Kocaturk Emek, Dagci Merve, Ece Ezgi
a Department of Dermatology, School of Medicine , Dumlupinar University , Kutahya , Turkey.
b Department of Public Health, School of Medicine , Dumlupinar University , Kutahya , Turkey.
Cutan Ocul Toxicol. 2018 Jun;37(2):167-171. doi: 10.1080/15569527.2017.1364261. Epub 2017 Aug 25.
Chronic exposure to inorganic arsenic is an important public health problem and leads to hyperpigmentation, hyperkeratosis, Bowen's disease and non-melanoma skin cancers in humans. Arsenic keratosis is the most common skin change that is associated with arsenic exposure. It may be an indicator of arsenic induced health hazards.
To determine the needs of patients with arsenic keratosis by evaluating the impact of disease on the quality of life with respect to treatment and provide rehabilitation services.
A total of 47 subjects with arsenic hyperkeratosis, were enrolled in this crossover study. The demographics, smoking status and the presence of chronic diseases diagnosed by the physician were recorded. Weight and height of the subjects were measured and BMI was calculated. The patients were asked to respond the visual analogue scale and EuroQoL-5D scales for assessing the pain and quality of life impairment associated with arsenic hyperkeratosis.
In the study group, moderate to severe problems were reported in 78.7% of patients for pain/uncomfortable condition domains and in 91.5% in anxiety/depression domains. Lower quality of life was reported in those with associated chronic disorders, at an advanced age, in thin patients and in those with severe lesions.
According to our knowledge, our study is the first one measuring the quality of life in patients with arsenic keratosis in the literature. By this study, we tried to underline the guidance of health services to be developed towards the needs of patients and the need for the development of new health policies by determining the requirements of these patients.
长期接触无机砷是一个重要的公共卫生问题，可导致人类出现色素沉着、角化过度、鲍恩病和非黑素瘤皮肤癌。砷角化病是与砷暴露相关的最常见皮肤改变。它可能是砷诱发健康危害的一个指标。
通过评估疾病对治疗方面生活质量的影响来确定砷角化病患者的需求，并提供康复服务。
本交叉研究共纳入47例砷角化病患者。记录人口统计学资料、吸烟状况以及医生诊断的慢性病情况。测量受试者的体重和身高并计算体重指数。要求患者对视觉模拟量表和欧洲五维健康量表作出反应，以评估与砷角化病相关的疼痛和生活质量损害。
在研究组中，78.7%的患者在疼痛/不适状况领域以及91.5%的患者在焦虑/抑郁领域报告有中度至重度问题。伴有慢性疾病、年龄较大、体型消瘦以及病变严重的患者报告的生活质量较低。
据我们所知，我们的研究是文献中首个测量砷角化病患者生活质量的研究。通过本研究，我们试图强调应根据患者需求制定卫生服务指南，并通过确定这些患者的需求来制定新的卫生政策。
