Mosaferi Mohammad, Yunesian Masud, Dastgiri Saeed, Mesdaghinia Alireza, Esmailnasab Nader
School of Public Health and Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
Sci Total Environ. 2008 Feb 1;390(1):69-76. doi: 10.1016/j.scitotenv.2007.09.035. Epub 2007 Nov 13.
Prevalence of skin lesions was investigated among 752 participants in eight villages in Kurdistan province in Iran with emphasis on total lifetime intake of arsenic from drinking water (TLIA). The participants were selected from eight villages with different exposure levels using a cluster-sampling technique. TLIA was calculated for each individual taking into account the type of water supply and their mean annual arsenic concentration. The study showed that 49 persons (6.5%) were suffering from hyperkeratosis and 20 persons (2.7%) from hyperpigmentation. The correlation between hyperkeratosis and hyperpigmentation was significant (R=0.325, p<0.01). Using the logistic regression model it was found that the relationship between TLIA and hyperkeratosis (OR=1.14, 95% CI=1.039-1.249), and hyperpigmentation (OR=1.254, 95% CI=1.112-1.416) was also significant. In conclusion, TLIA can be applied as a reliable indicator for the assessment of exposure.
在伊朗库尔德斯坦省八个村庄的752名参与者中，对皮肤病变的患病率进行了调查，重点是饮用水中砷的终生总摄入量（TLIA）。采用整群抽样技术从八个暴露水平不同的村庄中选取参与者。根据供水类型及其年均砷浓度，计算出每个人的TLIA。研究表明，49人（6.5%）患有角化过度，20人（2.7%）患有色素沉着。角化过度与色素沉着之间的相关性显著（R=0.325，p<0.01）。使用逻辑回归模型发现，TLIA与角化过度（OR=1.14，95%CI=1.039-1.249）以及色素沉着（OR=1.254，95%CI=1.112-1.416）之间的关系也很显著。总之，TLIA可作为评估暴露的可靠指标。
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