中国江苏省某农业地区产前和产后暴露于有机磷农药与婴儿神经发育的不良关联
Adverse Associations of both Prenatal and Postnatal Exposure to Organophosphorous Pesticides with Infant Neurodevelopment in an Agricultural Area of Jiangsu Province, China.
作者信息
Liu Ping, Wu Chunhua, Chang Xiuli, Qi Xiaojuan, Zheng Minglan, Zhou Zhijun
机构信息
School of Public Health/MOE Key Laboratory of Public Health Safety/WHO Collaborating Centre for Occupational Health (Shanghai), Fudan University, Shanghai, China.
出版信息
Environ Health Perspect. 2016 Oct;124(10):1637-1643. doi: 10.1289/EHP196. Epub 2016 May 6.
BACKGROUND
Prenatal exposure to organophosphorous (OP) pesticides has been found to be associated with adverse effects on child neurodevelopment, but evidence on potential effects induced by both prenatal and postnatal OP exposure in infants is limited.
OBJECTIVES
Our aim was to investigate the associations of both prenatal and postnatal OP exposure with birth outcomes and infant neurodevelopment.
METHODS
Exposure to OP in 310 mother-infant pairs was assessed by measuring dimethylphosphate (DM), diethylphosphate (DE), and total dialkylphosphate (DAP) metabolites in urines from pregnant women and their children at 2 years of age. The Gesell Developmental Schedules was administered to examine neurodevelopment of 2-year-old children.
RESULTS
Based on the Gesell Developmental Schedules, the proportions of children with developmental delays were < 6%. Adverse associations between head circumference at birth and prenatal OP exposure were demonstrated. Both prenatal and postnatal OP exposure was significantly associated with increased risk of being developmentally delayed. Specifically, odds ratio (OR) value for prenatal DEs was 9.75 (95% CI: 1.28, 73.98, p = 0.028) in the adaptive area, whereas in the social area, OR values for postnatal DEs and DAPs were 9.56 (95% CI: 1.59, 57.57, p = 0.014) and 12.00 (95% CI: 1.23, 117.37, p = 0.033), respectively. Adverse associations were observed only in boys, not in girls.
CONCLUSIONS
Both prenatal and postnatal OP exposure may adversely affect the neurodevelopment of infants living in the agricultural area. The present study adds to the accumulating evidence on associations of prenatal and postnatal OP exposure with infant neurodevelopment.
CITATION
Liu P, Wu C, Chang X, Qi X, Zheng M, Zhou Z. 2016. Adverse associations of both prenatal and postnatal exposure to organophosphorous pesticides with infant neurodevelopment in an agricultural area of Jiangsu Province, China. Environ Health Perspect 124:1637-1643; http://dx.doi.org/10.1289/EHP196.
背景
已发现产前接触有机磷（OP）农药与儿童神经发育的不良影响有关，但关于婴儿产前和产后OP暴露所引发的潜在影响的证据有限。
目的
我们的目的是调查产前和产后OP暴露与出生结局及婴儿神经发育之间的关联。
方法
通过测量310对母婴尿样中的二甲基磷酸酯（DM）、二乙基磷酸酯（DE）和总二烷基磷酸酯（DAP）代谢物，评估孕妇及其2岁儿童的OP暴露情况。采用格塞尔发育量表对2岁儿童的神经发育进行检查。
结果
根据格塞尔发育量表，发育迟缓儿童的比例<6%。研究表明出生时头围与产前OP暴露之间存在不良关联。产前和产后OP暴露均与发育迟缓风险增加显著相关。具体而言，在适应领域，产前DEs的优势比（OR）值为9.75（95%可信区间：1.28, 73.98，p = 0.028），而在社交领域产后DEs和DAPs的OR值分别为9.56（95%可信区间：1.59, 57.57，p = 0.014）和12.00（95%可信区间：1.23, 117.37，p = 0.033）。仅在男孩中观察到不良关联，女孩中未观察到。
结论
产前和产后OP暴露均可能对生活在农业地区的婴儿神经发育产生不利影响。本研究为产前和产后OP暴露与婴儿神经发育之间的关联增添了越来越多的证据。
引用文献
Liu P, Wu C, Chang X, Qi X, Zheng M, Zhou Z. 2016. 中国江苏省农业地区产前和产后暴露于有机磷农药与婴儿神经发育的不良关联。《环境健康展望》124:1637 - 1643；http://dx.doi.org/10.1289/EHP196 。
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