Khan Khalid M, Gaine Marie E, Daniel Alyssa R, Chilamkuri Pavani, Rohlman Diane S
Department of Public Health, College of Health Sciences, Sam Houston State University, 1901 Ave I, Huntsville, TX 77340, USA.
Department of Pharmaceutical Sciences and Experimental Therapeutics (PSET), College of Pharmacy, University of Iowa, 546 CPB, 180 S Grand Ave, Iowa City, IA 52242, USA; Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA 52242, USA.
Neurotoxicology. 2024 May;102:29-36. doi: 10.1016/j.neuro.2024.03.001. Epub 2024 Mar 6.
Organophosphorus pesticide (OP) exposure is known to have adverse effects on the nervous system. Children from agricultural communities are at risk of exposure to these chemicals from their indoor environments that can lead to neurological and developmental problems, including changes in behavior.
The aim of this study is to evaluate whether the take-home pathway exposure is associated with behavioral and emotional problems in Latino Orchid Community children.
The study was implemented over a period of two years (2008-2010) in an orchard farming community with a total of 324 parents who had children between the ages of 5-12 years old. Mothers of the children were asked to complete the Child Behavior Checklist (CBCL) and dust from their carpets was collected. Emotional and behavioral deficits were assessed based on the CBCL and house dust was assessed for OP concentrations. In this study, correlations between OPs in house dust and CBCL subscales were estimated using linear regression models with total OP concentrations classified by tertiles. This study also facilitated the comparison between the agricultural and non-agricultural families in terms of behavioral deficits and house dust concentrations of pesticides.
The data from the study shows that there was a positive association between the concentration of OP residues in house dust and internalizing behavior (β=2.06, p=0.05) whereas the association with externalizing behavior was not significant after accounting for sociocultural covariates. Significant positive associations of OP residues with somatic problems (p=0.02) and thought problems (p=0.05) were also found.
The data support a potential role of OP exposure in childhood development, with a specific focus on internalizing behavior. Future work focused on longitudinal studies may uncover the long-term consequences of OP exposure and behavior.
已知有机磷农药（OP）暴露会对神经系统产生不良影响。农业社区的儿童面临着从室内环境接触这些化学物质的风险，这可能导致神经和发育问题，包括行为改变。
本研究的目的是评估带回家途径的暴露是否与拉丁裔兰花社区儿童的行为和情绪问题相关。
该研究在一个果园种植社区进行了两年（2008 - 2010年），共有324名有5至12岁孩子的家长参与。研究要求孩子的母亲完成儿童行为检查表（CBCL），并收集她们家中地毯上的灰尘。根据CBCL评估情绪和行为缺陷，并评估房屋灰尘中的OP浓度。在本研究中，使用线性回归模型估计房屋灰尘中OP与CBCL子量表之间的相关性，总OP浓度按三分位数分类。本研究还促进了农业家庭和非农业家庭在行为缺陷和农药房屋灰尘浓度方面的比较。
研究数据表明，房屋灰尘中OP残留浓度与内化行为之间存在正相关（β = 2.06，p = 0.05），而在考虑社会文化协变量后，与外化行为的相关性不显著。还发现OP残留与躯体问题（p = 0.02）和思维问题（p = 0.05）之间存在显著正相关。
数据支持OP暴露在儿童发育中的潜在作用，尤其关注内化行为。未来专注于纵向研究的工作可能会揭示OP暴露与行为的长期后果。
