Effect of Frequency and Duration of Tobacco Use on Oral Mucosal Lesions – A Cross-Sectional Study among Tobacco Users in Hyderabad, India.

Purpose: Tobacco use is one of the most important risk factors for the development of oral mucosal lesions including oral pre-cancer and cancer. The type and location of the lesion varies with the type of tobacco used, the way it is used, and the frequency and duration of use. Hence, the present study aimed to determine the effect of frequency and duration of tobacco use on oral mucosal lesions among tobacco users in Hyderabad city. Materials and Methods: A cross-sectional study was carried out among 280 tobacco users who were categorized into smokers, chewers and mixed groups according to the habit. One forty subjects diagnosed with Oral Mucosal Lesions, designated as cases and One forty lesion free controls, frequency matched for age, gender, habit and family income were assessed. The study protocol included a visual oral soft tissue examination and a questionnaire-based interview. Statistical analysis was done using Chi square test and t- test. Multiple logistic regression analysis was done to assess the association of the variables with lesions. Results: Oral submucous fibrosis (18%) was the most common oral mucosal lesion followed by Leukoplakia (14%) and Smoker’s palate (12%). Dose-response relationships were observed for both duration and frequency of habits on the risk of oral mucosal lesions. However, it was significant only for frequency of the habit. A significant positive correlation was observed between occurrence of lesion and those with no education (p=0.005). Conclusion: The study revealed that frequency and duration of tobacco use was associated with the risk of oral mucosal lesions.