Vardam Trupti, Anandasabapathy Niroshana
Department of Dermatology/Harvard Skin Disease Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Department of Dermatology/Harvard Skin Disease Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
J Invest Dermatol. 2017 Sep;137(9):1826-1828. doi: 10.1016/j.jid.2017.06.014.
T follicular helper cells contribute to the development of long-lasting humoral immunity by germinal center formation. Somatic hypermutation and affinity maturation take place in germinal centers leading to the generation of memory B cells and plasma cells. As such, T follicular helper cells impact immunodeficiencies, autoimmunity, and cancer. This necessitates further understanding of how T follicular helper cells are regulated in health and disease. The current study by Levin et al. builds on prior work to further substantiate a critical role for skin migratory dendritic cells and in particular Langerhans cells at governing T follicular helper and germinal center formation after intradermal immunization with HIV p24-coated polylactic acid nanoparticles.
滤泡辅助性T细胞通过生发中心的形成促进持久的体液免疫发展。体细胞高频突变和亲和力成熟发生在生发中心，导致记忆B细胞和浆细胞的产生。因此，滤泡辅助性T细胞会影响免疫缺陷、自身免疫和癌症。这就需要进一步了解滤泡辅助性T细胞在健康和疾病状态下是如何被调节的。莱文等人的这项研究建立在先前工作的基础上，进一步证实了皮肤迁移性树突状细胞，尤其是朗格汉斯细胞，在经HIV p24包被的聚乳酸纳米颗粒皮内免疫后，在调控滤泡辅助性T细胞和生发中心形成方面的关键作用。
