Department of Traditional Medicine, Faculty of Iranian Traditional Medicine, Shahid Sadoughi University of Medical Sciences, Ardakan, Yazd 8951737915, Iran.
Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa 7461781189, Iran.
J Integr Med. 2017 Sep;15(5):365-372. doi: 10.1016/S2095-4964(17)60344-3.
Rheum ribes L. is a plant native to China, Iran, Turkey, India, and a few other countries. Antidiarrheal activity is considered to be one of its important properties according to various systems of traditional medicine. An increasing rate of bacterial resistance to antibiotics has led to treatment failure in some cases of shigellosis in children, and underlines a need for safe, efficient and valid options.
The purpose of this study is to evaluate the efficacy of R. ribes syrup as a complementary medicine for treatment of shigellosis in children.
DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: This randomized, double-blind, placebo-controlled trial started with a group of 150 children aged between 12-72 months with suspected Shigella dysentery. R. ribes syrup or placebo syrup was administered to the intervention and control groups, respectively for 5 days. In addition, the standard antibiotic treatment (ceftriaxone for the first 3 days and cefixime syrup for 2 further days) was administered to both groups.
Body temperature, abdominal pain, need for antipyretics, defecation frequency, stool volume and consistency and microscopic stool examination were recorded as outcome measures. Any observed adverse effects were also recorded.
Mean duration of fever and diarrhea in the R. ribes group was significantly lower than that in the placebo group (P = 0.016 and 0.001, respectively). In addition, patients in the R. ribes group showed shorter duration of need for antipyretics and shorter duration of abdominal pain (P = 0.012 and 0.001, respectively). However, there were no significant differences between the two groups regarding the microscopic stool analyses. Furthermore, no adverse effect was reported.
R. ribes syrup can be recommended as a complementary treatment for children with Shigella dysentery.
Iranian Registry of Clinical Trial: IRCT2014070518356N1.
糙叶树 Rheum ribes L. 原产于中国、伊朗、土耳其、印度和其他几个国家。根据各种传统医学体系，其具有止泻作用被认为是其重要特性之一。由于细菌对抗生素的耐药性不断增加，导致在某些儿童志贺氏菌病的治疗中出现了治疗失败的情况，这突显了需要安全、有效和有效的选择。
本研究旨在评估糙叶树糖浆作为治疗儿童志贺氏菌病的辅助药物的疗效。
设计、地点、参与者和干预措施：这是一项随机、双盲、安慰剂对照试验，最初纳入了 150 名年龄在 12-72 个月之间、疑似志贺氏菌痢疾的儿童。干预组和对照组分别给予糙叶树糖浆或安慰剂糖浆，疗程为 5 天。此外，两组均给予标准抗生素治疗（前 3 天用头孢曲松，后 2 天用头孢克肟糖浆）。
体温、腹痛、解热药需求、排便频率、粪便量和稠度以及粪便显微镜检查作为观察指标。还记录了任何观察到的不良反应。
糙叶树组的发热和腹泻持续时间明显短于安慰剂组（P=0.016 和 0.001）。此外，糙叶树组患者需要解热药的时间和腹痛持续时间更短（P=0.012 和 0.001）。然而，两组在粪便显微镜检查方面没有显著差异。此外，未报告不良反应。
糙叶树糖浆可作为儿童志贺氏菌病的辅助治疗药物。
伊朗临床试验注册处：IRCT2014070518356N1。
