Division of Gastrointestinal Sciences, Christian Medical College, Vellore, India.
Division of Gastrointestinal Sciences, Christian Medical College, Vellore, India.
Vaccine. 2018 Dec 14;36(51):7816-7819. doi: 10.1016/j.vaccine.2017.08.035. Epub 2017 Aug 31.
Diarrheal disease due to Group A rotaviruses remain a leading cause of mortality and morbidity in the less developed parts of the world. India has started a phased roll out of rotavirus vaccine in the national immunization program. This analysis summarizes the rotavirus genotype strain distribution pre-vaccine introduction in Vellore, India from December 2005 to June 2016. Rotavirus was responsible for 32% of all diarrheal admission to the hospital. G2P[4] was the predominant strain in the initial years and was gradually replaced by G1P[8]. The emergence of G9P[4] replacing G9P[8], and the detection of G12 strains over several years were documented. There was no clear seasonality of disease. These data form the baseline to monitor genotype distribution post-vaccine introduction in Tamil Nadu.
A 组轮状病毒引起的腹泻病仍然是世界欠发达地区死亡和发病的主要原因。印度已在国家免疫规划中逐步推出轮状病毒疫苗。本分析总结了印度维洛尔 2005 年 12 月至 2016 年 6 月疫苗接种前轮状病毒基因型和血清型的分布。轮状病毒导致所有住院腹泻患儿的 32%。在最初几年，G2P[4]是主要流行株，随后逐渐被 G1P[8]取代。已记录到 G9P[4]取代 G9P[8]和数年内 G12 株的出现。疾病无明显季节性。这些数据是监测泰米尔纳德邦疫苗接种后基因型分布的基线。
