Varghese Tintu, Alokit Khakha Shainey, Giri Sidhartha, Nair Nayana P, Badur Manohar, Gathwala Geeta, Chaudhury Sanjeev, Kaushik Shayam, Dash Mrutunjay, Mohakud Nirmal K, Ray Rajib K, Mohanty Prasantajyoti, Kumar Chethrapilly Purushothaman Girish, Venkatasubramanian Seshadri, Arora Rashmi, Raghava Mohan Venkata, E Tate Jacqueline, D Parashar Umesh, Kang Gagandeep
The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore 632004, India.
Department of Pediatrics, Sri Venkateshwara Medical College, Tirupati 517507, India.
Pathogens. 2021 Apr 1;10(4):416. doi: 10.3390/pathogens10040416.
In April 2016, an indigenous monovalent rotavirus vaccine (Rotavac) was introduced to the National Immunization Program in India. Hospital-based surveillance for acute gastroenteritis was conducted in five sentinel sites from 2012 to 2020 to monitor the vaccine impact on various genotypes and the reduction in rotavirus positivity at each site. Stool samples collected from children under 5 years of age hospitalized with diarrhea were tested for group A rotavirus using a commercial enzyme immunoassay, and rotavirus strains were characterized by RT-PCR. The proportion of diarrhea hospitalizations attributable to rotavirus at the five sites declined from a range of 56-29.4% in pre-vaccine years to 34-12% in post-vaccine years. G1P[8] was the predominant strain in the pre-vaccination period, and G3P[8] was the most common in the post-vaccination period. Circulating patterns varied throughout the study period, and increased proportions of mixed genotypes were detected in the post-vaccination phase. Continuous long-term surveillance is essential to understand the diversity and immuno-epidemiological effects of rotavirus vaccination.
2016年4月，一种本土单价轮状病毒疫苗（Rotavac）被引入印度国家免疫规划。2012年至2020年期间，在五个哨点开展了基于医院的急性胃肠炎监测，以监测该疫苗对各种基因型的影响以及每个哨点轮状病毒阳性率的降低情况。使用商业酶免疫测定法对5岁以下因腹泻住院儿童采集的粪便样本进行A组轮状病毒检测，并通过逆转录聚合酶链反应对轮状病毒毒株进行分型。五个哨点由轮状病毒引起的腹泻住院比例从疫苗接种前几年的56%-29.4%降至疫苗接种后几年的34%-12%。G1P[8]是疫苗接种前的主要毒株，G3P[8]是疫苗接种后最常见的毒株。在整个研究期间，流行模式各不相同，在疫苗接种后阶段检测到混合基因型的比例有所增加。持续的长期监测对于了解轮状病毒疫苗接种的多样性和免疫流行病学效应至关重要。
