Paschos Georgios K, FitzGerald Garret A
Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Smilow - 10th Floor, Room 122, Building 421, Philadelphia, PA 19104, USA.
Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Smilow - 10th Floor, Room 122, Building 421, Philadelphia, PA 19104, USA.
Trends Genet. 2017 Oct;33(10):760-769. doi: 10.1016/j.tig.2017.07.010. Epub 2017 Aug 24.
The circadian clock directs many aspects of metabolism, to separate in time opposing metabolic pathways and optimize metabolic efficiency. The master circadian clock of the suprachiasmatic nucleus synchronizes to light, while environmental cues such as temperature and feeding, out of phase with the light schedule, may synchronize peripheral clocks. This misalignment of central and peripheral clocks may be involved in the development of disease and the acceleration of aging, possibly in a gender-specific manner. Here we discuss the interplay between the circadian clock and metabolism, the importance of the microbiome, and how they relate to aging.
生物钟调控着新陈代谢的诸多方面，以便在时间上分离相互对立的代谢途径并优化代谢效率。视交叉上核的主生物钟与光线同步，而诸如温度和进食等与光照时间表不同步的环境线索可能使外周生物钟同步。中枢和外周生物钟的这种失调可能以性别特异性方式参与疾病的发生发展以及衰老的加速。在此，我们讨论生物钟与新陈代谢之间的相互作用、微生物群的重要性以及它们与衰老的关系。
