da Silva Marcelo S, Pavani Raphael S, Damasceno Jeziel D, Marques Catarina A, McCulloch Richard, Tosi Luiz Ricardo Orsini, Elias Maria Carolina
Laboratório Especial de Ciclo Celular (LECC), Center of Toxins, Immune Response and Cell Signaling (CeTICS), Butantan Institute, São Paulo, SP, Brazil.
Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
Trends Parasitol. 2017 Nov;33(11):858-874. doi: 10.1016/j.pt.2017.08.002. Epub 2017 Aug 24.
In trypanosomatids, etiological agents of devastating diseases, replication is robust and finely controlled to maintain genome stability and function in stressful environments. However, these parasites encode several replication protein components and complexes that show potentially variant composition compared with model eukaryotes. This review focuses on the advances made in recent years regarding the differences and peculiarities of the replication machinery in trypanosomatids, including how such divergence might affect DNA replication dynamics and the replication stress response. Comparing the DNA replication machinery and processes of parasites and their hosts may provide a foundation for the identification of targets that can be used in the development of chemotherapies to assist in the eradication of diseases caused by these pathogens.
在锥虫中，这些引发毁灭性疾病的病原体，其复制过程强大且受到精细调控，以在应激环境中维持基因组的稳定性和功能。然而，与模式真核生物相比，这些寄生虫编码的几种复制蛋白成分和复合物显示出潜在的不同组成。本综述聚焦于近年来在锥虫复制机制的差异和独特性方面取得的进展，包括这种差异如何影响DNA复制动态以及复制应激反应。比较寄生虫及其宿主的DNA复制机制和过程，可能为识别可用于开发化疗药物的靶点奠定基础，以帮助根除由这些病原体引起的疾病。
