Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran; Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Traditional Pharmacy, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran; Evidence-Based Medicine Group, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Pharmacol Res. 2018 Feb;128:338-344. doi: 10.1016/j.phrs.2017.08.009. Epub 2017 Aug 26.
Resveratrol is a natural dietary phenolic compound which is extensively present in many edible fruits, including grape, berries, pomegranates, and peanuts. Reseveratrol has a broad spectrum of biological activities including anti-aging, chemopreventive, anti-carcinogenic, anti-inflammatory and antioxidant effects and thus it is effective in related diseases. Particularly, the positive effects of resveratrol in neuropsychological diseases have been proven in in-vitro and in-vivo studies. Some clinical trials have reported that resveratrol possesses preventive and therapeutic effects in cognitive disorders. Therefore, the current systematic review and meta-analysis aimed to assess the effects of resveratrol on cognition and memory performance as well as mood state. Electronic databases including Scopus, PubMed, Science Direct, and Cochrane library were searched with the keywords "Memory", "Cognitive", "Cognition" or "Mood" with "Resveratrol" until June 2017. Only clinical studies were included in this review. We have provided the most reliable evidence to date counting results obtained from 226 individuals from four randomized clinical trials evaluating the mentioned specific effects of resveratrol. The results of this meta-analysis showed that resveratrol has no significant effect on memory and cognitive performance assessed by auditory verbal learning tests. Two parameters of Profile of Mood States (POMS) including vigor and fatigue, decreased significantly by resveratrol. However, decrease in other parameters of POMS including tense/anxiety, depression, anger, and confusion by resveratrol was not significant. The key findings from this meta-analysis are that resveratrol has no significant impact on factors related to memory and cognitive performance, including learning ability, delayed recall, retention, and recognition with all effect sizes non-significant and effectively at zero. However, it has the potential to enhance mood. Further randomized, controlled trials are needed to achieve more conclusive results.
白藜芦醇是一种天然的饮食多酚化合物，广泛存在于许多可食用的水果中，包括葡萄、浆果、石榴和花生。白藜芦醇具有广泛的生物活性，包括抗衰老、化学预防、抗癌、抗炎和抗氧化作用，因此对相关疾病有效。特别是，白藜芦醇在神经心理疾病中的积极作用已经在体外和体内研究中得到证明。一些临床试验报告称，白藜芦醇在认知障碍中具有预防和治疗作用。因此，本系统评价和荟萃分析旨在评估白藜芦醇对认知和记忆表现以及情绪状态的影响。电子数据库包括 Scopus、PubMed、Science Direct 和 Cochrane 图书馆，使用关键词“Memory”、“Cognitive”、“Cognition”或“Mood”与“Resveratrol”进行搜索，检索时间截至 2017 年 6 月。本综述仅纳入临床试验。我们提供了迄今为止最可靠的证据，结果来自 4 项随机临床试验的 226 名个体，评估了白藜芦醇的特定作用。荟萃分析结果表明，白藜芦醇对听觉言语学习测试评估的记忆和认知表现没有显著影响。白藜芦醇显著降低了心境状态问卷（POMS）的两个参数，包括活力和疲劳。然而，白藜芦醇对 POMS 的其他参数，包括紧张/焦虑、抑郁、愤怒和困惑，没有显著影响。这项荟萃分析的主要发现是，白藜芦醇对记忆和认知表现相关因素没有显著影响，包括学习能力、延迟回忆、保留和识别，所有效应量均不显著，实际上为零。然而，它有可能改善情绪。需要进一步的随机对照试验来获得更具结论性的结果。
