Zhang Qi, Zhang Lingyu, Li Shengnan, Chen Xiangjun, Zhang Manjie, Wang Tingting, Li Lu, Wang Chungang
Faculty of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China.
School of Chemistry & Environmental Engineering, Changchun University of Science and Technology, Changchun, 130022, P. R. China.
Chemistry. 2017 Dec 6;23(68):17242-17248. doi: 10.1002/chem.201703498. Epub 2017 Oct 9.
Elaborately designed novel multifunctional Janus nanoparticles (JNPs) have attracted considerable attention owing to their anisotropic surface properties and various functionalities that allow them to house several components for the detection and targeting of cancer cells. In this work, we report a novel and facile approach to synthesize Au/Fe O @C JNPs, which were further selectively functionalized with amino-poly(ethylene glycol)thiol (NH -PEG-SH) and folic acid (FA) on the exposed Au domains to achieve high contrast for X-ray computed tomography (CT) imaging, excellent stability, good biocompatibility, as well as cancer cell-specific targeting. Meanwhile, the other Fe O @C sides with mesoporous structure served as a drug delivery vehicle for doxorubicin (DOX), an efficient photothermal therapy (PTT) agent, and a magnetic resonance (MR) imaging contrast agent. Taking these features together, these unique multifunctional JNPs provide an intriguing nanoplatform for dual-modal CT and MR imaging-guided actively targeted chemo-photothermal synergistic cancer therapy.
精心设计的新型多功能Janus纳米粒子（JNPs）因其各向异性的表面性质和多种功能而备受关注，这些功能使它们能够容纳多种成分用于癌细胞的检测和靶向。在这项工作中，我们报告了一种新颖且简便的方法来合成Au/Fe₃O₄@C JNPs，其在暴露的Au域上进一步用氨基聚（乙二醇）硫醇（NH₂-PEG-SH）和叶酸（FA）进行选择性功能化，以实现X射线计算机断层扫描（CT）成像的高对比度、出色的稳定性、良好的生物相容性以及癌细胞特异性靶向。同时，具有介孔结构的另一侧Fe₃O₄@C用作阿霉素（DOX）的药物递送载体、高效光热疗法（PTT）剂和磁共振（MR）成像造影剂。综合这些特性，这些独特的多功能JNPs为双模态CT和MR成像引导的主动靶向化学-光热协同癌症治疗提供了一个引人入胜的纳米平台。
