Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
Chemistry. 2022 Dec 1;28(67):e202201861. doi: 10.1002/chem.202201861. Epub 2022 Oct 6.
Magnetic hyperthermia (MH) shows great potential in clinical applications because of its very localized action and minimal side effects. Because of their high saturation magnetization values, reduced forms of iron are promising candidates for MH. However, they must be protected in order to overcome their toxicity and instability (i. e., oxidation) under biological conditions. In this work, a novel methodology for the protection of iron nanoparticles through confinement within graphitic carbon layers after thermal treatment of preformed nanoparticles supported on carbon is reported. We demonstrate that the size and composition of the nascent confined iron nanoparticles, as well as the thickness of their protective carbon layer can be controlled by selecting the nature of the carbon support. Our findings reveal that a higher nanoparticle-carbon interaction, mediated by the presence of oxygen-containing groups, induces the formation of small and well-protected α-Fe-based nanoparticles that exhibit promising results towards MH based on their enhanced specific absorption rate values.
磁热疗（MH）由于其非常局部的作用和最小的副作用，在临床应用中显示出巨大的潜力。由于其高饱和磁化强度值，还原态的铁是 MH 的有前途的候选物。然而，为了克服它们在生物条件下的毒性和不稳定性（即氧化），它们必须加以保护。在这项工作中，报道了一种通过在预形成的纳米粒子负载在碳上进行热处理后将其限制在石墨碳层内来保护铁纳米粒子的新方法。我们证明，初生的受限铁纳米粒子的尺寸和组成，以及其保护性碳层的厚度可以通过选择碳载体的性质来控制。我们的研究结果表明，通过存在含氧基团来介导的更高的纳米粒子-碳相互作用，诱导形成小而得到良好保护的基于α-Fe 的纳米粒子，这些纳米粒子在基于其增强的比吸收率值的 MH 方面表现出有前景的结果。
