Chen Xiangjun, Li Guilan, Han Qinghe, Li Xiliang, Li Lu, Wang Tingting, Wang Chungang
Faculty of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China.
Radiology, The Second Hospital of Jilin University, Changchun, 130022, P. R. China.
Chemistry. 2017 Dec 6;23(68):17204-17208. doi: 10.1002/chem.201704514. Epub 2017 Nov 20.
We report a facile and simple hydrogen reduction method to fabricate PEGylated branched gold (Au)-iron oxide (Fe O ) Janus nanoparticles (JNPs). Note that the hydrogen induces the formation of Fe O during the synthesis process. Due to the strong absorption in the near-infrared range, branched Au-Fe O JNPs showed a significant photothermal effect with a 40 % calculated photothermal transduction efficiency under a laser irradiation of 808 nm in vitro. Owing to their excellent optical and magnetic properties, branched Au-Fe O JNPs were demonstrated to be advantageous agents for triple-modal magnetic resonance imaging (MRI)/photoacoustic imaging (PAI)/computed tomography (CT) in vitro. Therefore, the synthetic approach could be extended to prepare Au-metallic oxide JNPs for specific applications.
我们报道了一种简便的氢还原方法来制备聚乙二醇化的分支状金（Au）-氧化铁（Fe₃O₄）Janus纳米颗粒（JNPs）。请注意，在合成过程中氢气会诱导Fe₃O₄的形成。由于在近红外范围内有强烈吸收，分支状Au-Fe₃O₄ JNPs在808 nm激光照射下在体外表现出显著的光热效应，计算得到的光热转换效率为40%。由于其优异的光学和磁性特性，分支状Au-Fe₃O₄ JNPs在体外被证明是用于三模态磁共振成像（MRI）/光声成像（PAI）/计算机断层扫描（CT）的优势试剂。因此，该合成方法可扩展用于制备特定应用的Au-金属氧化物JNPs。
