Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA.
Section of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Nutrients. 2017 Aug 28;9(9):949. doi: 10.3390/nu9090949.
Osteoarthritis (OA), the most common form of arthritis, is a significant public health burden in U.S. adults. Among its many risk factors, obesity is a key player, causing inflammation, pain, impaired joint function, and reduced quality of life. Dietary polyphenols and other bioactive compounds in berries, curcumin, and tea have shown effects in ameliorating pain and inflammation in OA, but few clinical studies have been reported. The purpose of the present study was to examine the effects of dietary strawberries on pain, markers of inflammation, and quality of life indicators in obese adults with OA of the knee. In a randomized, double-blind cross-over trial, adults with radiographic evidence of knee OA ( = 17; body mass index (BMI): (mean ± SD) 39.1 ± 1.5; age (years): 57 ± 7) were randomized to a reconstituted freeze-dried strawberry beverage (50 g/day) or control beverage daily, each for 12 weeks, separated by a 2-week washout phase (total duration, 26 weeks). Blood draws and assessments of pain and quality of life indicators were conducted using the Visual Analog Scale for Pain (VAS Pain), Measures of Intermittent and Constant Osteoarthritis Pain (ICOAP), and Health Assessment Questionnaire-Disability Index (HAQ-DI) questionnaires, which were completed at baseline and at weeks 12, 14, and 26 of the study. Among the serum biomarkers of inflammation and cartilage degradation, interleukin (IL)-6, IL-1β, and matrix metalloproteinase (MMP)-3 were significantly decreased after strawberry vs. control treatment (all < 0.05). Strawberry supplementation also significantly reduced constant, intermittent, and total pain as evaluated by the ICOAP questionnaire as well as the HAQ-DI scores (all < 0.05). No effects of treatment were noted on serum C-reactive protein (CRP), nitrite, glucose, and lipid profiles. Dietary strawberries may have significant analgesic and anti-inflammatory effects in obese adults with established knee OA.
骨关节炎（OA）是最常见的关节炎形式，是美国成年人的重大公共卫生负担。在其众多风险因素中，肥胖是一个关键因素，会导致炎症、疼痛、关节功能受损和生活质量下降。浆果中的膳食多酚和其他生物活性化合物、姜黄素和茶已显示出在改善 OA 疼痛和炎症方面的作用，但很少有临床研究报道。本研究的目的是研究饮食中草莓对肥胖 OA 膝关节患者疼痛、炎症标志物和生活质量指标的影响。在一项随机、双盲交叉试验中，有膝关节 OA 放射学证据的成年人（=17；体重指数（BMI）：（均值±标准差）39.1±1.5；年龄（岁）：57±7）被随机分配到每天服用再水化冻干草莓饮料（50g/天）或对照饮料，各持续 12 周，间隔 2 周洗脱期（总持续时间 26 周）。通过视觉模拟量表（VAS 疼痛）、间歇性和持续性骨关节炎疼痛测量（ICOAP）和健康评估问卷残疾指数（HAQ-DI）问卷进行血液采集和疼痛及生活质量指标评估，这些问卷在研究的基线以及第 12、14 和 26 周进行评估。在炎症和软骨降解的血清生物标志物中，与对照处理相比，草莓处理后白细胞介素（IL）-6、IL-1β和基质金属蛋白酶（MMP）-3 显著降低（均<0.05）。草莓补充剂还显著降低了 ICOAP 问卷和 HAQ-DI 评分评估的持续、间歇性和总疼痛（均<0.05）。治疗对血清 C 反应蛋白（CRP）、亚硝酸盐、葡萄糖和血脂谱没有影响。饮食中草莓可能对患有已确诊膝关节 OA 的肥胖成年人具有显著的镇痛和抗炎作用。
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