Deepika Ramachandran, Girigoswami Koyeli, Murugesan Ramachandran, Girigoswami Agnishwar
Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research & Education (CARE), Kelambakkam, Chennai 603 103, India.
Curr Drug Deliv. 2018;15(5):652-657. doi: 10.2174/1567201814666170825160617.
Biopolymeric nanoparticles comprising chitosan-alginate have attracted interest in drug delivery due to their protective nature, biocompatibility, biodegradability and hydrophilicity.
The present study was designed to encapsulate levofloxacin in chitosan-alginate hybrid gel for controlled release and to evaluate the effect of divalent alkaline earth metal ions (Mg2+, Ca2+, Sr2+, Ba2+) on encapsulation efficiency and drug release kinetics considering their role in polyelectrolyte gelation method.
Divalent metal ions control the rigidity and elasticity of the hydrogels and have the ability to change the shape and size of nanostructure formed by chitosan-alginate. The particle size increases and encapsulation efficiency decreases with the size of the divalent ions. Spherical shaped particles were formed by Mg2+ and Ca2+, whereas Sr2+ and Ba2+ produced non-spherical particles.
SEM image clearly shows transformation of sphere to truncated tetrahedron by Sr2+ and clear rod shape by Ba2+.
Therefore, it is concluded that metal ions have significant influence on the morphology and drug encapsulation and release profile of the chitosan-alginate hybrid polymer nanoparticles.
由壳聚糖-海藻酸盐组成的生物聚合物纳米颗粒因其保护性、生物相容性、生物降解性和亲水性，在药物递送方面引起了关注。
本研究旨在将左氧氟沙星包封在壳聚糖-海藻酸盐混合凝胶中以实现控释，并考虑二价碱土金属离子（Mg2+、Ca2+、Sr2+、Ba2+）在聚电解质凝胶化方法中的作用，评估其对包封效率和药物释放动力学的影响。
二价金属离子控制水凝胶的刚性和弹性，并能够改变由壳聚糖-海藻酸盐形成的纳米结构的形状和大小。随着二价离子尺寸的增加，粒径增大且包封效率降低。Mg2+和Ca2+形成球形颗粒，而Sr2+和Ba2+产生非球形颗粒。
扫描电子显微镜图像清楚地显示了Sr2+使球体转变为截顶四面体，Ba2+使颗粒呈清晰的棒状。
因此，可以得出结论，金属离子对壳聚糖-海藻酸盐混合聚合物纳米颗粒的形态以及药物包封和释放曲线具有显著影响。
