Gomez-Bautista M, Rojo-Vazquez F A, Alunda J M
Vet Parasitol. 1987 Apr;24(1-2):47-57. doi: 10.1016/0304-4017(87)90129-4.
The pathology of experimental Eimeria stiedai infection in 2- and 4-month-old rabbits raised coccidia-free was studied. Over 50 days of infection, the serum activities of aspartate (AST) and alanine (ALT) aminotransferases, alkaline phosphatase (AP) and gamma-glutamyltranspeptidase (GGTP) were analyzed as indicators of hepatic lesions and total serum globulins with respect to the immune response of the host; parasite development was followed by oocyst output; weight gain, food intake and relative liver weight were analyzed to control the performance of infected animals. The age of the host strongly affected parasite development and consequently the biochemical and zootechnical parameters differed more markedly in the younger animals; however, the enzyme ALT showed an increase independent of parasite development, and infection did not affect GGTP activity. The increase in age was responsible for resistance of rabbits to hepatic coccidiosis and older animals were less affected than young ones.
对无球虫饲养的2月龄和4月龄兔子的斯氏艾美耳球虫实验性感染病理学进行了研究。在超过50天的感染期内，分析了天冬氨酸（AST）和丙氨酸（ALT）氨基转移酶、碱性磷酸酶（AP）和γ-谷氨酰转肽酶（GGTP）的血清活性，作为肝脏损伤的指标，并分析了血清总球蛋白与宿主免疫反应的关系；通过卵囊排出量追踪寄生虫发育情况；分析体重增加、食物摄入量和相对肝脏重量，以控制受感染动物的表现。宿主年龄对寄生虫发育有强烈影响，因此年幼动物的生化和畜牧学参数差异更为明显；然而，酶ALT的升高与寄生虫发育无关，且感染不影响GGTP活性。年龄增长导致兔子对肝球虫病产生抗性，年长动物比年幼动物受影响更小。
