San Martín-Núñez B V, Ordóñez-Escudero D, Alunda J M
Departamento de Farmacología y Toxicología, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain.
Vet Parasitol. 1988 Nov;30(1):1-10. doi: 10.1016/0304-4017(88)90137-9.
The effect of alpha-difluoromethylornithine (DFMO) administered in drinking water (0.2 and 0.5%) against liver and intestinal coccidioses in experimentally infected rabbits was studied. Zootechnical and clinical parameters were used to assess the efficacy of the compound. In both coccidioses the lower dose did not show any important effect. The higher dosage (0.5%) however, reduced the lesions induced by coccidia to an important extent. The animals infected and treated with 0.5% DFMO showed similar weight gain, food intake and relative liver weight figures to the non-infected controls. Serum transaminase levels in the rabbits infected with Eimeria stiedai and treated with 0.5% DFMO were close to those of the non-infected animals. Infected rabbits treated with this dosage also showed reductions (over 80%) in faecal oocyst output.
研究了饮用水中添加α-二氟甲基鸟氨酸（DFMO）（0.2%和0.5%）对实验感染兔肝脏和肠道球虫病的影响。采用畜牧学和临床参数评估该化合物的疗效。在两种球虫病中，较低剂量均未显示出任何显著效果。然而，较高剂量（0.5%）在很大程度上减轻了球虫引起的病变。感染并用0.5% DFMO治疗的动物体重增加、食物摄入量和相对肝脏重量数据与未感染对照组相似。感染斯氏艾美耳球虫并用0.5% DFMO治疗的兔血清转氨酶水平接近未感染动物。用该剂量治疗的感染兔粪便中卵囊排出量也减少了（超过80%）。
