Gómez-Bautista M, Rojo-Vázquez F A
Res Vet Sci. 1986 Jul;41(1):28-32.
The activity of a mixture of sulphadimethoxine and pyrimethamine (10:3) as prophylactic medication and prophylactic and therapeutic medication was studied in rabbits experimentally infected with Eimeria stiedai. The haematocrit index (packed cell volume) and haemoglobin levels were studied for assessment of drug toxicity. The activity in serum of aspartate aminotransferase (AST) and alanine aminotransferase, alkaline phosphatase and gamma-glutamyltranspeptidase were studied as indicators of hepatic lesions. Parasite development was followed on the basis of the presence of oocysts; other parameters were analysed in order to monitor the performance of infected animals. All the parameters studied showed that the chemoprophylactic medication provided efficient control of the infection and of the hepatic lesions. Serum AST activity was seen to be a good indicator of the effect of the drugs on the liver.
研究了磺胺二甲氧嘧啶与乙胺嘧啶（10:3）混合物作为预防性药物以及预防性和治疗性药物，对实验感染斯氏艾美耳球虫的家兔的作用。通过研究血细胞比容指数（红细胞压积）和血红蛋白水平来评估药物毒性。研究血清中天冬氨酸转氨酶（AST）、丙氨酸转氨酶、碱性磷酸酶和γ-谷氨酰转肽酶的活性，作为肝损伤的指标。根据卵囊的存在情况跟踪寄生虫发育；分析其他参数以监测受感染动物的状况。所有研究参数均表明，化学预防药物能有效控制感染和肝损伤。血清AST活性被视为药物对肝脏作用效果的良好指标。
