Wang Jingru, Wu Yuying, Li Jie, Huang Xinyuan, Zhu Rongfei
Department of Allergy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Int Arch Allergy Immunol. 2017;173(4):193-198. doi: 10.1159/000479429. Epub 2017 Aug 29.
The prevalence of allergic rhinitis (AR) is increasing rapidly in Central China. The skin prick test (SPT) is the standard tool with which to determine the allergen sensitization status in AR patients. Changes in allergen sensitization patterns have been observed within countries and regions due to geographical and seasonal variations.
The aim of this study was to evaluate the profile of SPT reactivity to different aeroallergens in AR patients and to suggest a minimal panel of allergens to detect sensitized patients in Central China.
From January 2015 to December 2016, patients who presented to Tongji Hospital with suspected AR were tested with the same panel of 19 aeroallergens. The results of SPT were analyzed to determine the minimum test battery panel necessary to cover 99% of the cases of SPT sensitization in different age subgroups.
A total of 2,416 patients (male:female ratio 1.2:1) were enrolled in our study with an average age of 22.0 years. The overall rate of sensitization to any allergen was 79.0%, and 64.3% of the subjects were monosensitized. The highest sensitized rate was found in the subgroup aged 14-18 years (92.0%), followed by the subgroups of 6-14 years (86.4%), >18 years (75.6%), and ≤6 years (74.9%). The most common sensitization was to Dermatophagoides farinae (71.1%). Testing with 8 allergens (D. pteronyssinus, D. farinae, Platanus, Artemisia, Cryptomeria, Blatella germanica, Humulus, and Alternaria) was sufficient to identify over 99% of the sensitized patients.
An SPT panel covering 8 allergen extracts was able to detect almost all sensitized patients suffering from AR symptoms in Central China.
在中国中部地区，过敏性鼻炎（AR）的患病率正在迅速上升。皮肤点刺试验（SPT）是确定AR患者过敏原致敏状态的标准工具。由于地理和季节差异，在不同国家和地区已观察到过敏原致敏模式的变化。
本研究旨在评估AR患者对不同空气过敏原的SPT反应情况，并提出一组最小化的过敏原组合，以检测中国中部地区的致敏患者。
2015年1月至2016年12月，前往同济医院就诊且疑似患有AR的患者接受了相同的19种空气过敏原检测。分析SPT结果，以确定在不同年龄亚组中覆盖99%的SPT致敏病例所需的最小检测组合。
本研究共纳入2416例患者（男女比例为1.2:1），平均年龄为22.0岁。对任何过敏原的总体致敏率为79.0%，64.3%的受试者为单一致敏。致敏率最高的是14-18岁亚组（92.0%），其次是6-14岁亚组（86.4%）、>18岁亚组（75.6%）和≤6岁亚组（74.9%）。最常见的致敏原是粉尘螨（71.1%）。检测8种过敏原（屋尘螨、粉尘螨、悬铃木、蒿属植物、柳杉、德国小蠊、葎草和链格孢）足以识别超过99%的致敏患者。
在中国中部地区，一组包含8种过敏原提取物的SPT检测组合能够检测出几乎所有患有AR症状的致敏患者。
