Bonsack Frederick, Alleyne Cargill H, Sukumari-Ramesh Sangeetha
Department of Neurosurgery, Medical College of Georgia, Augusta UniversityAugusta, GA, United States.
Front Cell Neurosci. 2017 Aug 8;11:228. doi: 10.3389/fncel.2017.00228. eCollection 2017.
Intracerebral hemorrhage (ICH) is a devastating type of stroke with a substantial public health impact. Currently, there is no effective treatment for ICH. The purpose of the study was to evaluate whether the post-injury administration of Resveratrol confers neuroprotection in a pre-clinical model of ICH. To this end, ICH was induced in adult male CD1 mice by collagenase injection method. Resveratrol (10 mg/kg) or vehicle was administered at 30 min post-induction of ICH and the neurobehavioral outcome, neurodegeneration, cerebral edema, hematoma resolution and neuroinflammation were assessed. The Resveratrol treatment significantly attenuated acute neurological deficits, neurodegeneration and cerebral edema after ICH in comparison to vehicle treated controls. Further, Resveratrol treated mice exhibited improved hematoma resolution with a concomitant reduction in the expression of proinflammatory cytokine, IL-1β after ICH. Altogether, the data suggest the efficacy of post-injury administration of Resveratrol in improving acute neurological function after ICH.
脑出血（ICH）是一种具有重大公共卫生影响的毁灭性中风类型。目前，脑出血尚无有效的治疗方法。本研究的目的是评估白藜芦醇在脑出血临床前模型中损伤后给药是否具有神经保护作用。为此，采用胶原酶注射法在成年雄性CD1小鼠中诱导脑出血。在脑出血诱导后30分钟给予白藜芦醇（10mg/kg）或赋形剂，并评估神经行为结果、神经变性、脑水肿、血肿消退和神经炎症。与赋形剂处理的对照组相比，白藜芦醇治疗显著减轻了脑出血后的急性神经功能缺损、神经变性和脑水肿。此外，白藜芦醇治疗的小鼠血肿消退改善，同时脑出血后促炎细胞因子IL-1β的表达降低。总之，数据表明白藜芦醇损伤后给药在改善脑出血后急性神经功能方面的有效性。
