Cui Zhuang, Wang Qian, Gao Yayue, Wang Jing, Wang Mengyang, Teng Pengfei, Guan Yuguang, Zhou Jian, Li Tianfu, Luan Guoming, Li Liang
Beijing Key Laboratory of Epilepsy, Epilepsy Center, Department of Functional Neurosurgery, Sanbo Brain Hospital, Capital Medical UniversityBeijing, China.
Beijing HospitalBeijing, China.
Front Hum Neurosci. 2017 Aug 11;11:407. doi: 10.3389/fnhum.2017.00407. eCollection 2017.
The arrival of sound signals in the auditory cortex (AC) triggers both local and inter-regional signal propagations over time up to hundreds of milliseconds and builds up both intrinsic functional connectivity (iFC) and extrinsic functional connectivity (eFC) of the AC. However, interactions between iFC and eFC are largely unknown. Using intracranial stereo-electroencephalographic recordings in people with drug-refractory epilepsy, this study mainly investigated the temporal dynamic of the relationships between iFC and eFC of the AC. The results showed that a Gaussian wideband-noise burst markedly elicited potentials in both the AC and numerous higher-order cortical regions outside the AC (non-auditory cortices). Granger causality analyses revealed that in the earlier time window, iFC of the AC was positively correlated with both eFC from the AC to the inferior temporal gyrus and that to the inferior parietal lobule. While in later periods, the iFC of the AC was positively correlated with eFC from the precentral gyrus to the AC and that from the insula to the AC. In conclusion, dual-directional interactions occur between iFC and eFC of the AC at different time windows following the sound stimulation and may form the foundation underlying various central auditory processes, including auditory sensory memory, object formation, integrations between sensory, perceptional, attentional, motor, emotional, and executive processes.
声音信号到达听觉皮层（AC）会随着时间推移触发局部和区域间的信号传播，持续数百毫秒，并建立起AC的内在功能连接（iFC）和外在功能连接（eFC）。然而，iFC和eFC之间的相互作用在很大程度上尚不清楚。本研究利用药物难治性癫痫患者的颅内立体脑电图记录，主要探究了AC的iFC和eFC之间关系的时间动态变化。结果显示，高斯宽带噪声脉冲在AC以及AC之外的许多高阶皮层区域（非听觉皮层）均显著诱发了电位。格兰杰因果分析表明，在较早的时间窗内，AC的iFC与从AC到颞下回以及到顶下小叶的eFC均呈正相关。而在较晚时期，AC的iFC与从前中央回至AC以及从脑岛至AC的eFC呈正相关。总之，声音刺激后，AC的iFC和eFC在不同时间窗存在双向相互作用，这可能构成了包括听觉感觉记忆、客体形成、感觉、知觉、注意、运动、情感和执行过程之间整合等各种中枢听觉过程的基础。
