Rozenblat Vanja, Ryan Joanne, Wertheim Eleanor H, King Ross, Olsson Craig A, Krug Isabel
School of Psychological Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, ParkvilleVIC, Australia.
Murdoch Childrens Research Institute, Royal Children's Hospital Melbourne, ParkvilleVIC, Australia.
Front Psychol. 2017 Aug 9;8:1361. doi: 10.3389/fpsyg.2017.01361. eCollection 2017.
To examine the relationship between psychological and social factors (depression, emotional control, sexual abuse, and parental physical punishment) and adolescent drive for Thinness and Bulimic behaviors in a large community sample, and to investigate possible genetic moderation. Data were drawn from the Australian Temperament Project (ATP), a population-based cohort study that has followed a representative sample of 2443 participants from infancy to adulthood across 16 waves since 1983. A subsample of 650 participants (50.2% female) of Caucasian descent who provided DNA were genotyped for a serotonin transporter promoter polymorphism (). Adolescent disordered eating attitudes and behaviors were assessed using the Bulimia and Drive for Thinness scales of the Eating Disorder Inventory-2 (15-16 years). Depression and emotional control were examined at the same age using the Short Mood and Feelings Questionnaire, and an ATP-devised measure of emotional control. History of sexual abuse and physical punishment were assessed retrospectively (23-24 years) in a subsample of 467 of those providing DNA. EDI-2 scores were associated with depression, emotional control, and retrospectively reported parental physical punishment. Although there was statistically significant moderation of the relationship between parental physical punishment and bulimic behaviors by ( = 0.0048), genotypes in this subsample were not in Hardy-Weinberg Equilibrium. No other G×E interactions were significant. Findings from this study affirm the central importance of psychosocial processes in disordered eating patterns in adolescence. Evidence of moderation by was not conclusive; however, genetic moderation observed in a subsample not in Hardy-Weinberg Equilibrium warrants further investigation.
为了在一个大型社区样本中研究心理和社会因素（抑郁、情绪控制、性虐待和父母体罚）与青少年追求瘦身及暴食行为之间的关系，并调查可能的基因调节作用。数据取自澳大利亚气质项目（ATP），这是一项基于人群的队列研究，自1983年以来，对2443名参与者的代表性样本进行了16次随访，从婴儿期到成年期。对650名提供DNA的高加索血统参与者（50.2%为女性）的子样本进行了血清素转运体启动子多态性基因分型。使用饮食失调问卷-2（15 - 16岁）的暴食和追求瘦身量表评估青少年的饮食失调态度和行为。在相同年龄使用简短情绪和感受问卷以及ATP设计的情绪控制测量方法来检查抑郁和情绪控制情况。在提供DNA的467名参与者的子样本中，回顾性评估性虐待和体罚史（23 - 24岁）。EDI - 2得分与抑郁、情绪控制以及回顾性报告的父母体罚有关。虽然父母体罚与暴食行为之间的关系存在统计学上显著的调节作用（ = 0.0048），但该子样本中的基因型不符合哈迪 - 温伯格平衡。没有其他基因×环境相互作用是显著的。本研究结果证实了心理社会过程在青少年饮食失调模式中的核心重要性。基因调节的证据并不确凿；然而，在一个不符合哈迪 - 温伯格平衡的子样本中观察到的基因调节值得进一步研究。
