伴有智力发育迟缓的手镜细胞白血病：免疫学、染色体及形态学研究

Hand-mirror cell leukemia associated with mental retardation: immunologic, chromosome, and morphological studies.

作者信息

Stern R, Widirstky S T, Wurster-Hill D H, Allen R D, Smith K A, Cornwell G G, Cornell C J

出版信息

Blood. 1979 Sep;54(3):703-12.

Abstract

Cycochemical, morphological, immunologic, and cytogenetic studies were carried out on hand-mirror cells (HMC) from a mentally retarded patient with a constitutional chromosome abnormality, 46,XX,r(21), and acute lymphoblastic leukemia. Scanning electron and differential interference contrast microscopy showed microspikes on the uropodia, but little evidence of cellular motility, despite formation and disappearance of individual uropodia in cell suspensions. The cells rosetted with sheep erythrocytes, suggesting T-cell origin. Cells derived from the bone marrow (80% HMC) showed a high degree of polyploidy (60%) and a bimodal chromosome number of 49 (49,XX,+10,-21, +3 rings) and 94 (6 no. 10, 3 no. 18, 2 no. 21 chromosomes, 3 ring chromosomes, plus 4 copies of each other chromosome).

摘要

对一名患有先天性染色体异常（46,XX,r(21)）的智障患者及急性淋巴细胞白血病患者的手镜细胞（HMC）进行了细胞化学、形态学、免疫学和细胞遗传学研究。扫描电子显微镜和微分干涉相差显微镜显示尿足上有微刺，但尽管细胞悬液中单个尿足有形成和消失现象，细胞运动的证据却很少。这些细胞与绵羊红细胞形成玫瑰花结，提示其起源于T细胞。来自骨髓的细胞（80%为HMC）显示出高度的多倍体性（60%），染色体数目呈双峰，分别为49（49,XX,+10,-21,+3个环状染色体）和94（6条10号染色体、3条18号染色体、2条21号染色体、3个环状染色体，加上其他每条染色体各4份拷贝）。