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从气管体音中检测呼吸暂停和心率以诊断与睡眠相关的呼吸障碍。

Apnea and heart rate detection from tracheal body sounds for the diagnosis of sleep-related breathing disorders.

机构信息

Faculty of Medical Engineering, University of Applied Science Ulm, Albert-Einstein-Allee 55, 89075, Ulm, Germany.

Department of Internal Medicine II, University Hospital Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany.

出版信息

Med Biol Eng Comput. 2018 Apr;56(4):671-681. doi: 10.1007/s11517-017-1706-y. Epub 2017 Aug 29.

Abstract

Sleep apnea is one of the most common sleep disorders. Here, patients suffer from multiple breathing pauses longer than 10 s during the night which are referred to as apneas. The standard method for the diagnosis of sleep apnea is the attended cardiorespiratory polysomnography (PSG). However, this method is expensive and the extensive recording equipment can have a significant impact on sleep quality falsifying the results. To overcome these problems, a comfortable and novel system for sleep monitoring based on the recording of tracheal sounds and movement data is developed. For apnea detection, a unique signal processing method utilizing both signals is introduced. Additionally, an algorithm for extracting the heart rate from body sounds is developed. For validation, ten subjects underwent a full-night PSG testing, using the developed sleep monitor in concurrence. Considering polysomnography as gold standard the developed instrumentation reached a sensitivity of 92.8% and a specificity of 99.7% for apnea detection. Heart rate measured with the proposed method was strongly correlated with heart rate derived from conventional ECG (r  = 0.8164). No significant signal losses are reported during the study. In conclusion, we demonstrate a novel approach to reliably and noninvasively detect both apneas and heart rate during sleep.

摘要

睡眠呼吸暂停是最常见的睡眠障碍之一。在这里,患者在夜间会多次出现超过 10 秒的呼吸暂停。睡眠呼吸暂停的标准诊断方法是有医护人员在场的心肺多导睡眠图(PSG)。然而,这种方法费用昂贵,广泛的记录设备会对睡眠质量产生重大影响,从而使结果产生偏差。为了克服这些问题,开发了一种基于记录气管声音和运动数据的舒适且新颖的睡眠监测系统。为了进行睡眠呼吸暂停检测,引入了一种利用两种信号的独特信号处理方法。此外,还开发了一种从体声中提取心率的算法。在验证过程中,十个受试者进行了整夜 PSG 测试,同时使用开发的睡眠监测器进行监测。以多导睡眠图为金标准,所开发的仪器在检测睡眠呼吸暂停方面的灵敏度为 92.8%,特异性为 99.7%。所提出的方法测量的心率与传统心电图(ECG)得出的心率高度相关(r=0.8164)。研究过程中没有报告明显的信号丢失。总之,我们展示了一种可靠且无创的方法,可在睡眠期间可靠地检测呼吸暂停和心率。

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