牛磺酸在胎儿和新生儿大脑发育中的作用。
Functions of Maternally-Derived Taurine in Fetal and Neonatal Brain Development.
机构信息
Division of Development of Mental Functions, Research Center for Child Mental Development, University of Fukui, Fukui, 910-1193, Japan.
Division of Developmental Higher Brain Functions, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, 565-0871, Japan.
出版信息
Adv Exp Med Biol. 2017;975 Pt 1:17-25. doi: 10.1007/978-94-024-1079-2_2.
Taurine (2-aminoethanesulfonic acid) is a sulfur-containing organic acid, which has various physiological functions, including membrane stabilization, cell-volume regulation, mitochondrial protein translocation, anti-oxidative activity, neuroprotection against neurotoxicity and modulation of intracellular calcium levels. Taurine also activates GABA receptors and glycine receptors. Mammalian fetuses and infants are dependent on taurine delivered from their mothers via either the placenta or their mother's milk. Taurine is a molecule that links mother-fetus or mother-infant bonding.This review describes the functions of taurine and the mechanisms of action of taurine in fetal and brain development. Taurine is involved in regulating the proliferation of neural progenitors, migration of newly-generated neurons, and the synapse formation of neurons after migration during fetal and neonatal development. In this review, we also discuss the environmental factors that might influence the functional roles of taurine in neural development.
牛磺酸（2-氨基乙磺酸）是一种含硫的有机酸，具有多种生理功能，包括膜稳定、细胞体积调节、线粒体蛋白易位、抗氧化活性、神经保护作用、神经毒性和细胞内钙离子水平的调节。牛磺酸还能激活 GABA 受体和甘氨酸受体。哺乳动物的胎儿和婴儿依赖于母体通过胎盘或母乳提供的牛磺酸。牛磺酸是一种将母亲与胎儿或母亲与婴儿联系起来的分子。本综述描述了牛磺酸的功能以及牛磺酸在胎儿和大脑发育中的作用机制。牛磺酸参与调节神经祖细胞的增殖、新生成的神经元的迁移以及神经元迁移后的突触形成。在本综述中，我们还讨论了可能影响牛磺酸在神经发育中功能作用的环境因素。
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