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牛磺酸在大脑中的意义。

Significance of Taurine in the Brain.

机构信息

Tampere University Medical School, Tampere, Finland.

出版信息

Adv Exp Med Biol. 2017;975 Pt 1:89-94. doi: 10.1007/978-94-024-1079-2_8.

DOI:10.1007/978-94-024-1079-2_8
PMID:28849446
Abstract

Two main functions of taurine in the brain are here discussed: the role of taurine in cell volume regulation and the neuromodulatory actions of taurine liberated by depolarization. Taurine takes part in cell volume regulation with other small-molecular compounds. Extracellular taurine inhibits neuronal firing through GABA and glycine receptors. However, the existence of specific taurine receptors is still not excluded.

摘要

在这里,我们将讨论牛磺酸在大脑中的两个主要功能:牛磺酸在细胞体积调节中的作用和去极化释放的牛磺酸的神经调制作用。牛磺酸与其他小分子化合物一起参与细胞体积调节。细胞外牛磺酸通过 GABA 和甘氨酸受体抑制神经元放电。然而,仍不能排除特定的牛磺酸受体的存在。

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Significance of Taurine in the Brain.牛磺酸在大脑中的意义。
Adv Exp Med Biol. 2017;975 Pt 1:89-94. doi: 10.1007/978-94-024-1079-2_8.
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Taurine enhances proliferation and promotes neuronal specification of murine and human neural stem/progenitor cells.牛磺酸可增强小鼠和人类神经干细胞/祖细胞的增殖并促进其神经元分化。
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Actions of taurine on the GABA-benzodiazepine receptor complex solubilized from rat brain.牛磺酸对从大鼠脑中溶解出的γ-氨基丁酸-苯二氮䓬受体复合物的作用。
Neurochem Int. 1987;11(1):113-7. doi: 10.1016/0197-0186(87)90157-4.
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Taurine and brain excitability.牛磺酸与大脑兴奋性。
Adv Exp Med Biol. 2006;583:315-22. doi: 10.1007/978-0-387-33504-9_35.
3
Taurine prevents ammonia-induced accumulation of cyclic GMP in rat striatum by interaction with GABAA and glycine receptors.牛磺酸通过与γ-氨基丁酸A受体和甘氨酸受体相互作用,防止氨诱导的大鼠纹状体中环磷酸鸟苷的积累。
长期使用安非他命导致组织中谷氨酸和谷氨酰胺能神经递质调质牛磺酸和犬尿氨酸水平的破坏。
Psychopharmacology (Berl). 2024 Jul;241(7):1387-1398. doi: 10.1007/s00213-024-06570-4. Epub 2024 Mar 14.
4
Taurine Chloramine-Mediated Nrf2 Activation and HO-1 Induction Confer Protective Effects in Astrocytes.牛磺酸氯胺介导的Nrf2激活和HO-1诱导赋予星形胶质细胞保护作用。
Antioxidants (Basel). 2024 Jan 29;13(2):169. doi: 10.3390/antiox13020169.
5
Targeting the metabolic profile of amino acids to identify the key metabolic characteristics in cerebral palsy.针对氨基酸代谢谱以识别脑瘫的关键代谢特征。
Front Mol Neurosci. 2023 Aug 17;16:1237745. doi: 10.3389/fnmol.2023.1237745. eCollection 2023.
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Oxidative stress, dysfunctional energy metabolism, and destabilizing neurotransmitters altered the cerebral metabolic profile in a rat model of simulated heliox saturation diving to 4.0 MPa.氧化应激、能量代谢障碍和神经递质不稳定改变了模拟氦氧饱和潜水至 4.0 MPa 时大鼠模型的脑代谢特征。
PLoS One. 2023 Mar 14;18(3):e0282700. doi: 10.1371/journal.pone.0282700. eCollection 2023.
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Digoxin Induces Human Astrocyte Reaction In Vitro.地高辛在体外诱导人星形胶质细胞反应。
Mol Neurobiol. 2023 Jan;60(1):84-97. doi: 10.1007/s12035-022-03057-1. Epub 2022 Oct 12.
8
Editorial for Special Issue on "Regulation and Effect of Taurine on Metabolism".“牛磺酸对代谢的调节作用及影响”专题社论
Metabolites. 2022 Aug 26;12(9):795. doi: 10.3390/metabo12090795.
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Taurine and Astrocytes: A Homeostatic and Neuroprotective Relationship.牛磺酸与星形胶质细胞:一种稳态与神经保护的关系
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10
The effects of taurine supplementation on diabetes mellitus in humans: A systematic review and meta-analysis.补充牛磺酸对人类糖尿病的影响:一项系统评价和荟萃分析。
Food Chem (Oxf). 2022 Mar 21;4:100106. doi: 10.1016/j.fochms.2022.100106. eCollection 2022 Jul 30.
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Influence of protein tyrosine kinases on cell volume change-induced taurine release.蛋白酪氨酸激酶对细胞体积变化诱导的牛磺酸释放的影响。
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Neurochem Res. 2000 Jun;25(6):801-7. doi: 10.1023/a:1007513423270.
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Neuroscience. 1999 Apr;90(1):303-17. doi: 10.1016/s0306-4522(98)00430-8.
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Kinetic analysis of taurine influx into cerebral cortical slices from adult and developing mice in different incubation conditions.不同孵育条件下成年和发育中小鼠大脑皮质切片中牛磺酸流入的动力学分析。
Neurochem Res. 1996 Feb;21(2):161-6. doi: 10.1007/BF02529133.