, 4-16, Edagawa Town, Hyogo Pref., Nishinomiya City, 663-8143, Japan.
Laboratory of Preventive Nutritional Medicine, Research Institute for Production and Development, 15, Shimogamo Morimotocho, Sakyoku, Kyoto City, 606-8413, Japan.
Adv Exp Med Biol. 2017;975 Pt 2:1011-1020. doi: 10.1007/978-94-024-1079-2_80.
WHO-CARDIAC (Cardiovascular Diseases and Alimentary Comparison) Study revealed the quintile analyses of 24-h urinary (24 U) taurine (T) and magnesium (Mg) excretions were inversely related with cardiometabolic risks (CMR) such as obesity, hypertension and hypercholesterolemia in 50 population samples in the world. To exclude the influence of ethnicity in the study, 24 U T and Mg excretions were analyzed for the association with CMR in one ethnicity, Japanese population.24 U T/creatinine (C) ratios were divided into 5 quintiles and the ratios of Japanese to the total of each quintile were analyzed from CARDIAC Study samples. The highest 24 U T quintile consisted of 60% Japanese, indicating high seafood consumption in Japanese.Over 600 Japanese aged 30-79 were invited to a health examination for blood pressure measurement and for fasting blood and 24 U samplings. Tertile analysis of 24 U T/C ratios in relation to CMR indicated the third tertile had significantly higher HDL cholesterol, 24 U potassium (K) and 24 U salt than the first (lowest) tertile. Tertile analysis of 24 U Mg/C ratios indicated the third tertile had significantly lower body mass index and significantly higher folic acid, 24 U isoflavones, K and salt than the first tertile after age and gender adjustment. The third tertile of both T/C and Mg/C had significantly lower body mass index, LDL/HDL and Na/K ratios, and significantly higher HDL cholesterol and folic acid than the first tertile, indicating seafood eaters taking Mg rich diets had lower risks of obesity, atherosclerosis, hypertension and higher folic acid, beneficial for healthy longevity.
世界 50 个人群样本的 WHO-CARDIAC（心血管疾病和营养比较）研究显示，24 小时尿（24 U）牛磺酸（T）和镁（Mg）排泄的五分位数分析与肥胖、高血压和高胆固醇血症等代谢相关心血管风险（CMR）呈负相关。为了排除研究中种族的影响，在一个种族，日本人群中分析了 24 U T 和 Mg 排泄与 CMR 的关系。24 U T/肌酐（C）比值分为 5 个五分位数，分析了来自 CARDIAC 研究样本的日本人群每个五分位数的比值。最高的 24 U T 五分位数包括 60%的日本人，表明日本人摄入大量海鲜。邀请了 600 多名年龄在 30-79 岁的日本人进行健康检查，测量血压，采集空腹血和 24 U 样本。24 U T/C 比值与 CMR 的三分位分析表明，第三分位的高密度脂蛋白胆固醇、24 U 钾（K）和 24 U 盐显著高于第一分位（最低分位）。24 U Mg/C 比值的三分位分析表明，在年龄和性别调整后，第三分位的体重指数显著较低，叶酸、24 U 异黄酮、K 和盐显著较高。T/C 和 Mg/C 的第三分位的体重指数、LDL/HDL 和 Na/K 比值显著较低，高密度脂蛋白胆固醇和叶酸显著较高，表明摄入富含镁的海鲜的人群患肥胖症、动脉粥样硬化、高血压的风险较低，叶酸水平较高，有利于健康长寿。
