Yamori Yukio, Liu Longjian, Mori Mari, Sagara Miki, Murakami Shigeru, Nara Yasuo, Mizushima Shunsaku
Mukogawa Women's University, Japan.
Adv Exp Med Biol. 2009;643:13-25. doi: 10.1007/978-0-387-75681-3_2.
The initial observation that taurine (T) prevented stroke in stroke-prone spontaneously hypertensive rats (SHRSP) led us to study the effects of T on cardiovascular diseases (CVD), as well as the epidemiological association of T and mortality rates, by using the data from WHO-coordinated Cardiovascular Disease and Alimentary Comparison Study, which covered 61 populations in 25 countries. In this study, 24 hour urine (24-U) samples were examined along with biomarkers of CVD risk. The mortality rate from ischemic heart disease (IHD), which was lowest among the Japanese compared to the populations of other developed countries, was positively related to total serum cholesterol (TC) and inversely related to 24-U taurine excretion (24-UT), as well as the n-3 fatty acid to total phospholipids ratio of the plasma membrane, both biomarkers of seafood intake. Analysis of 5 diet-related factors revealed that TC and BMI were positively associated with IHD mortality in both genders while Mg and T were negatively associated with IHD mortality. TC and sodium (Na) were negatively and positively associated with stroke mortality, respectively. 24-UT was negatively associated with stroke mortality. These five diet-related factors explained 61 and 49% of IHD and stroke variances in male, 63 and 36% of IHD and stroke variances in female, respectively.
最初观察到牛磺酸（T）可预防易患中风的自发性高血压大鼠（SHRSP）发生中风，这促使我们利用世界卫生组织协调的心血管疾病与饮食比较研究（该研究涵盖了25个国家的61个人群）的数据，来研究T对心血管疾病（CVD）的影响以及T与死亡率之间的流行病学关联。在这项研究中，对24小时尿液（24-U）样本以及CVD风险生物标志物进行了检测。与其他发达国家人群相比，日本人群中缺血性心脏病（IHD）的死亡率最低，该死亡率与血清总胆固醇（TC）呈正相关，与24-U牛磺酸排泄量（24-UT）呈负相关，同时也与细胞膜中n-3脂肪酸与总磷脂的比例呈负相关，这两个指标都是海鲜摄入量的生物标志物。对5个与饮食相关的因素进行分析发现，TC和体重指数（BMI）在男女两性中均与IHD死亡率呈正相关，而镁（Mg）和T与IHD死亡率呈负相关。TC和钠（Na）分别与中风死亡率呈负相关和正相关。24-UT与中风死亡率呈负相关。这5个与饮食相关的因素分别解释了男性IHD和中风变异的61%和49%，女性IHD和中风变异的63%和36%。
