Perucho-González Lucía, Méndez-Hernández Carmen Dora, González-de-la-Rosa Manuel, Fernández-Pérez Cristina, Sáez-Francés Federico, Andrés-Guerrero Vanesa, García-Feijoó Julián
J Pediatr Ophthalmol Strabismus. 2017 Nov 1;54(6):387-394. doi: 10.3928/01913913-20170801-02. Epub 2017 Aug 29.
To evaluate the effectiveness of quantifying color changes in the optic nerve head in retinal photographs of patients with childhood glaucoma.
In this observational study, three photographs of the optic nerve head were obtained in 28 patients with childhood glaucoma and 28 age- and sex-matched healthy participants (the childhood glaucoma and control groups, respectively). The Laguna Optic Nerve Head Hemoglobin (ONhE) software (Insoft SL, Tenerife, Spain) was used to determine hemoglobin levels in the optic nerve head. The following parameters were quantified: the hemoglobin levels in the optic nerve head across the whole disc, in 24 sectors (the optic nerve head divided by two concentric rings and eight 45-degree radial sectors), and in the vertical disc diameter (sectors 8 and 20), and the estimated cup-disc ratio and Glaucoma Discriminant Function, which combines the slope of the hemoglobin amount with the mean vertical disc diameter.
Patient ages ranged from 9 to 14 years (median: 11 years) in the childhood glaucoma group, and 7 to 13 years (median: 9 years) in the control group (P < .061). Eyes in the childhood glaucoma group showed a significantly higher cup-disc ratio compared to eyes in the control group (0.6 ± 0.2 vs 0.5 ± 0.1, respectively; P < .0001). In the childhood glaucoma group, the Glaucoma Discriminant Function was found to be significantly lower than in the control group (-6.5 ± 31.1 vs 9.4 ± 17.1, respectively; P < .0001). There were no significant differences in the hemoglobin levels in the optic nerve head across the whole disc between eyes in the childhood glaucoma and control groups (58.2% ± 10.9% vs 58.5% ± 6.7%, respectively; P = .847). The Laguna ONhE software showed good reproducibility in measuring percentages of hemoglobin levels in both groups.
The Laguna ONhE software is useful for patients with childhood glaucoma. However, hemoglobin levels in the optic nerve head across the whole disc may have normal values. This method had good reliability and is easy to implement in routine clinical practice. [J Pediatr Ophthalmol Strabismus. 2017;54(6):387-394.].
评估量化儿童青光眼患者视网膜照片中视神经乳头颜色变化的有效性。
在这项观察性研究中，分别获取了28例儿童青光眼患者和28例年龄及性别匹配的健康参与者（分别为儿童青光眼组和对照组）的三张视神经乳头照片。使用拉古纳视神经乳头血红蛋白（ONhE）软件（Insoft SL，西班牙特内里费岛）测定视神经乳头中的血红蛋白水平。对以下参数进行量化：整个视盘、24个扇形区域（视盘由两个同心圆和八个45度径向扇形区域划分）以及垂直视盘直径（第8和20扇形区域）中的视神经乳头血红蛋白水平，以及估计的杯盘比和青光眼判别函数，该函数将血红蛋白量的斜率与平均垂直视盘直径相结合。
儿童青光眼组患者年龄范围为9至14岁（中位数：11岁），对照组为7至13岁（中位数：9岁）（P <.061）。儿童青光眼组的眼睛杯盘比显著高于对照组（分别为0.6±0.2和0.5±0.1；P <.0001）。在儿童青光眼组中，发现青光眼判别函数显著低于对照组（分别为-6.5±31.1和9.4±17.1；P <.0001）。儿童青光眼组和对照组眼睛的整个视盘视神经乳头血红蛋白水平无显著差异（分别为58.2%±10.9%和58.5%±6.7%；P =.847）。拉古纳ONhE软件在测量两组血红蛋白水平百分比方面具有良好的重复性。
拉古纳ONhE软件对儿童青光眼患者有用。然而，整个视盘的视神经乳头血红蛋白水平可能具有正常数值。该方法具有良好的可靠性，且易于在常规临床实践中实施。[《小儿眼科与斜视杂志》。2017；54(6)：387 - 394。]
