α-血影蛋白在小鼠1号染色体远端的定位

Mapping of alpha-spectrin on distal mouse chromosome 1.

作者信息

Seldin M F, Morse H C, D'Hoostelaere L, Britten J L, Steinberg A D

出版信息

Cytogenet Cell Genet. 1987;45(1):52-4. doi: 10.1159/000132424.

DOI:10.1159/000132424

Abstract

DNAs from different strains of inbred mice and feral Mus spretus were found to exhibit restriction fragment length polymorphisms (RFLP) when hybridized with a probe prepared from a c-DNA clone of the mouse alpha-spectrin (Spna-1) gene. Studies of five recombinant inbred strains and (C57BL/6 X M. spretus) F1 X C57BL/6 backcross mice demonstrated that these RFLPs were allelic and that Spna-1 is closely linked to Ly-9 and Ly-17 on the distal region of chromosome 1.

摘要

当用从小鼠α-血影蛋白（Spna-1）基因的一个cDNA克隆制备的探针进行杂交时，发现来自不同近交系小鼠和野生小家鼠的DNA表现出限制性片段长度多态性（RFLP）。对五个重组近交系以及（C57BL/6×小家鼠）F1×C57BL/6回交小鼠的研究表明，这些RFLP是等位基因，并且Spna-1与位于1号染色体远端区域的Ly-9和Ly-17紧密连锁。

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