自身免疫性gld小鼠的基因分析。I. 在一个保守连锁群中鉴定与gld突变紧密连锁的限制性片段长度多态性。
Genetic analysis of autoimmune gld mice. I. Identification of a restriction fragment length polymorphism closely linked to the gld mutation within a conserved linkage group.
作者信息
Seldin M F, Morse H C, Reeves J P, Scribner C L, LeBoeuf R C, Steinberg A D
机构信息
Cellular Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892.
出版信息
J Exp Med. 1988 Feb 1;167(2):688-93. doi: 10.1084/jem.167.2.688.
Abstract
A linkage map of distal mouse chromosome 1 was generated using restriction fragment length polymorphism (RFLP) analysis of DNA prepared from 95 [C3H-gld/gld X Mus spretus)F1 X C3H-gld/gld] backcross mice. The gene order was: (centromere) C4bp, Ren-1,2, Ly-5, [At-3/gld], Apoa-2/Ly-17, Spna-1 (telomere). All mice expressing the phenotype of gld homozygotes were homozygous for the At-3 RFLP characteristic of C3H mice and none of the mice heterozygous for At-3 RFLPs had characteristics of gld homozygotes, demonstrating close linkage between these genes. The identification of an RFLP closely linked to the gld gene provides a starting point for the identification of a genetic defect that results in abnormal T cells and autoimmune disease.
摘要
利用从95只[C3H-gld/gld×小家鼠]F1×C3H-gld/gld回交小鼠制备的DNA进行限制性片段长度多态性（RFLP）分析，构建了小鼠1号染色体远端的连锁图谱。基因顺序为：（着丝粒）C4bp、Ren-1,2、Ly-5、[At-3/gld]、Apoa-2/Ly-17、Spna-1（端粒）。所有表现出gld纯合子表型的小鼠对于C3H小鼠特有的At-3 RFLP都是纯合的，并且没有At-3 RFLP杂合的小鼠具有gld纯合子的特征，这证明了这些基因之间紧密连锁。与gld基因紧密连锁的RFLP的鉴定为鉴定导致异常T细胞和自身免疫性疾病的遗传缺陷提供了一个起点。
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本文引用的文献
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