Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Semin Cell Dev Biol. 2018 Sep;81:110-120. doi: 10.1016/j.semcdb.2017.08.043. Epub 2017 Aug 26.
Low oxygen adaptation is essential for aerobic fungi that must survive in varied oxygen environments. Pathogenic fungi in particular must adapt to the low oxygen host tissue environment in order to cause infection. Maintenance of lipid homeostasis is especially important for cell growth and proliferation, and is a highly oxygen-dependent process. In this review, we focus on recent advances in our understanding of the transcriptional regulation and coordination of the low oxygen response across fungal species, paying particular attention to pathogenic fungi. Comparison of lipid homeostasis pathways in these organisms suggests common mechanisms of transcriptional regulation and points toward untapped potential to target low oxygen adaptation in antifungal development.
低氧适应对于必须在各种氧环境中生存的需氧真菌至关重要。特别是致病真菌必须适应低氧宿主组织环境才能引起感染。维持脂质动态平衡对于细胞生长和增殖尤为重要，这是一个高度依赖氧的过程。在这篇综述中，我们重点介绍了近年来对真菌物种低氧反应的转录调控和协调的理解的最新进展，特别关注了致病真菌。对这些生物体内脂质动态平衡途径的比较表明，转录调控存在共同的机制，并指出在抗真菌药物开发中靶向低氧适应的潜力尚未被充分挖掘。
