"Carol Davila" University of Medicine and Pharmacy, Chair of Medical Genetics, 020032 Bucharest, Romania; Genome Life Research Centre, 020961 Bucharest, Romania.
National Institute of Endocrinology "C. I. Parhon", 011863 Bucharest, Romania.
Mitochondrion. 2018 Mar;39:43-50. doi: 10.1016/j.mito.2017.08.012. Epub 2017 Aug 26.
We aimed to analyze the contribution of mitochondrial DNA (mtDNA) haplogroups of the mtDNA control region to thyroid cancer risk in a population from southeastern Europe consisting of 235 thyroid tumor patients, including 114 patients with thyroid follicular adenoma, 121 patients with papillary thyroid carcinoma, and 419 healthy controls. Binary logistic regression with adjustment for age and gender revealed that mtDNA haplogroup K was significantly associated with a protective role for thyroid cancer in the combined tumor group versus controls. These results indicate a potential role for mtDNA haplogroups as important candidate susceptibility markers for the patients with thyroid nodules.
我们旨在分析线粒体 DNA（mtDNA）控制区的线粒体 DNA（mtDNA）单倍群在一个来自东南欧的人群中对甲状腺癌风险的贡献，该人群包括 235 例甲状腺肿瘤患者，其中 114 例为甲状腺滤泡性腺瘤，121 例为甲状腺乳头状癌，419 例为健康对照。经过年龄和性别调整的二元逻辑回归显示，mtDNA 单倍群 K 与甲状腺癌在联合肿瘤组与对照组相比具有保护作用显著相关。这些结果表明，mtDNA 单倍群作为甲状腺结节患者的重要候选易感性标志物可能具有重要作用。
