Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Sci Rep. 2017 Aug 29;7(1):9853. doi: 10.1038/s41598-017-09255-5.
This study was performed to compare the area of the foveal avascular zone (FAZ-area) obtained by three optical coherence tomography angiography (OCTA) instruments. This was a cross-sectional, non-interventional study of twenty-seven healthy right eyes. The superficial and deep FAZ-area was measured manually with three OCTA instruments: Triton (Topcon), RS3000 (Nidek), and CIRRUS (Zeiss). The intra-rater, inter-rater, and inter-instrument correlation coefficients (CC) were assessed. The intra-rater and inter-rater CC were significantly high for the superficial and deep FAZ-areas (P < 0.001). The inter-instrument CC (95% confidence interval) for the superficial FAZ-area was 0.920 (0.803-0.965) for Triton vs RS3000, 0.899 (0.575-0.965) for RS3000 vs CIRRUS, and was 0.963 (0.913-0.983) for CIRRUS vs Triton (P < 0.001). For the deep FAZ-area, the inter-instrument CC was 0.813 (0.633-0.910) for Triton vs RS3000, 0.694 (0.369-0.857) for RS3000 vs CIRRUS, and 0.679 (0.153-0.872) for CIRRUS vs Triton (P < 0.001). The superficial FAZ-area (mm) was 0.264 ± 0.071 with Triton, 0.278 ± 0.072 with RS3000 and 0.257 ± 0.066 with CIRRUS. For deep FAZ-area, it was 0.617 ± 0.175 with Triton, 0.646 ± 0.178 with RS3000 and 0.719 ± 0.175 with CIRRUS. The FAZ-area from these instruments was clinically interchangeable. However, the absolute values of FAZ-area are significantly different among them. These differences must be considered in comparing the FAZ-areas from different OCTA instruments.
本研究旨在比较三种光学相干断层扫描血管造影（OCTA）仪器测量的中心凹无血管区（FAZ）面积。这是一项对 27 只健康右眼进行的横断面、非干预性研究。使用三种 OCTA 仪器（Triton、RS3000 和 Cirrus）手动测量浅层和深层 FAZ 区域。评估了内部观察者、外部观察者和仪器间的相关系数（CC）。浅层和深层 FAZ 区域的内部观察者和外部观察者 CC 显著较高（P<0.001）。浅层 FAZ 区域的仪器间 CC（95%置信区间）为 Triton 与 RS3000 之间为 0.920（0.803-0.965），RS3000 与 Cirrus 之间为 0.899（0.575-0.965），Cirrus 与 Triton 之间为 0.963（0.913-0.983）（P<0.001）。对于深层 FAZ 区域，仪器间 CC 为 Triton 与 RS3000 之间为 0.813（0.633-0.910），RS3000 与 Cirrus 之间为 0.694（0.369-0.857），Cirrus 与 Triton 之间为 0.679（0.153-0.872）（P<0.001）。浅层 FAZ 区域（mm）用 Triton 为 0.264±0.071，用 RS3000 为 0.278±0.072，用 Cirrus 为 0.257±0.066。深层 FAZ 区域用 Triton 为 0.617±0.175，用 RS3000 为 0.646±0.178，用 Cirrus 为 0.719±0.175。这些仪器的 FAZ 区域在临床上可互换。然而，它们之间 FAZ 区域的绝对值有显著差异。在比较不同 OCTA 仪器的 FAZ 区域时，必须考虑这些差异。
