Zhang Lei, Wang Lin-Mei, Chen Wei-Wei, Ma Zhi, Han Xiao, Liu Cheng-Ming, Cheng Xiang, Shi Wei, Guo Jing-Jing, Qin Jian-Bing, Yang Xiao-Qing, Jin Guo-Hua, Zhang Xin-Hua
Department of Anatomy, Nantong University, Nantong, Jiangsu Province, China.
Department of Radiation Oncology, Third People's Hospital of Yancheng, Yancheng, Jiangsu Province, China.
Neural Regen Res. 2017 Jul;12(7):1103-1110. doi: 10.4103/1673-5374.211189.
Human Wharton's jelly-derived mesenchymal stem cells (hWJ-MSCs) have excellent proliferative ability, differentiation ability, low immunogenicity, and can be easily obtained. However, there are few studies on their application in the treatment of ischemic stroke, therefore their therapeutic effect requires further verification. In this study, hWJ-MSCs were transplanted into an ischemic stroke rat model the tail vein 48 hours after transient middle cerebral artery occlusion. After 4 weeks, neurological functions of the rats implanted with hWJ-MSCs were significantly recovered. Furthermore, many hWJ-MSCs homed to the ischemic frontal cortex whereby they differentiated into neuron-like cells at this region. These results confirm that hWJ-MSCs transplanted into the ischemic stroke rat can differentiate into neuron-like cells to improve rat neurological function and behavior.
人脐带华通氏胶间充质干细胞（hWJ-MSCs）具有出色的增殖能力、分化能力、低免疫原性，且易于获取。然而，关于其在缺血性脑卒中治疗中的应用研究较少，因此其治疗效果有待进一步验证。在本研究中，在短暂性大脑中动脉闭塞48小时后，通过尾静脉将hWJ-MSCs移植到缺血性脑卒中大鼠模型中。4周后，植入hWJ-MSCs的大鼠神经功能明显恢复。此外，许多hWJ-MSCs归巢至缺血的额叶皮质，并在该区域分化为神经元样细胞。这些结果证实，移植到缺血性脑卒中大鼠体内的hWJ-MSCs可分化为神经元样细胞，从而改善大鼠的神经功能和行为。
