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脐带间充质干细胞治疗动物模型缺血性脑卒中的疗效及潜在机制：一项荟萃分析

Efficacy and Potential Mechanisms of Umbilical Cord-Derived Mesenchymal Stem Cells in the Treatment of Ischemic Stroke in Animal Models: A Meta-Analysis.

作者信息

Wei Renli, Yang Minguang, Cao Yue, Qiu Shuqian, Fan Xu, Fang Muxuan, Chen Li, Cheng Shaojie, Li Jianhong, Zhang Shenghang

机构信息

Fujian Key Laboratory of Aptamers Technology, Fuzhou General Teaching Hospital (The 900th Hospital), Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.

College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.

出版信息

CNS Neurosci Ther. 2025 Apr;31(4):e70357. doi: 10.1111/cns.70357.

DOI:10.1111/cns.70357
PMID:40202099
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11979713/
Abstract

BACKGROUND

Umbilical cord-derived mesenchymal stem cells (UCMSCs) have emerged as a promising treatment for ischemic stroke. This study aimed to evaluate the therapeutic efficacy and potential mechanisms of UCMSCs in treating ischemic stroke.

METHODS

A systematic search of PubMed, Web of Science, and Embase was conducted up to April 25, 2024. Literature was screened based on the PICOS principle, with predefined inclusion and exclusion criteria. Relevant data were extracted and analyzed using Review Manager 5.4.

RESULTS

Out of 1390 retrieved articles, 30 were included in the meta-analysis. UCMSCs significantly reduced infarct size and volume, improved neurological deficit scores, and facilitated neurobehavioral recovery. UCMSCs treatment also modulated inflammatory cytokine levels in brain tissue and serum, promoted microglial polarization, inhibited apoptosis, and increased vessel density in the peri-infarct tissue.

CONCLUSIONS

UCMSCs administration significantly promoted the neurological function recovery after ischemic stroke. Their mechanisms of action may be related to immune response regulation, inhibition of apoptosis, and promotion of angiogenesis. These findings provide theoretical guidance for improving the quality of basic research and clinical translation.

摘要

背景

脐带间充质干细胞（UCMSCs）已成为缺血性中风的一种有前景的治疗方法。本研究旨在评估UCMSCs治疗缺血性中风的疗效及潜在机制。

方法

截至2024年4月25日，对PubMed、Web of Science和Embase进行了系统检索。根据PICOS原则筛选文献，设定了预定义的纳入和排除标准。使用Review Manager 5.4提取并分析相关数据。

结果

在检索到的1390篇文章中，有30篇被纳入荟萃分析。UCMSCs显著减小了梗死灶大小和体积，改善了神经功能缺损评分，并促进了神经行为恢复。UCMSCs治疗还调节了脑组织和血清中的炎性细胞因子水平，促进了小胶质细胞极化，抑制了细胞凋亡，并增加了梗死周边组织的血管密度。

结论

给予UCMSCs可显著促进缺血性中风后神经功能的恢复。其作用机制可能与免疫反应调节、抑制细胞凋亡和促进血管生成有关。这些发现为提高基础研究和临床转化质量提供了理论指导。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e2/11979713/b5d6cca67e70/CNS-31-e70357-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e2/11979713/d01d2599f345/CNS-31-e70357-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e2/11979713/faf71079f699/CNS-31-e70357-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e2/11979713/b15f8ad5afee/CNS-31-e70357-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e2/11979713/9d7966174ebb/CNS-31-e70357-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e2/11979713/35ed39affd2e/CNS-31-e70357-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e2/11979713/bd768ec877b2/CNS-31-e70357-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e2/11979713/3f940537d9b7/CNS-31-e70357-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e2/11979713/8f61118075f5/CNS-31-e70357-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e2/11979713/b5d6cca67e70/CNS-31-e70357-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e2/11979713/d01d2599f345/CNS-31-e70357-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e2/11979713/faf71079f699/CNS-31-e70357-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e2/11979713/b15f8ad5afee/CNS-31-e70357-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e2/11979713/9d7966174ebb/CNS-31-e70357-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e2/11979713/35ed39affd2e/CNS-31-e70357-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e2/11979713/bd768ec877b2/CNS-31-e70357-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e2/11979713/3f940537d9b7/CNS-31-e70357-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e2/11979713/8f61118075f5/CNS-31-e70357-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e2/11979713/b5d6cca67e70/CNS-31-e70357-g002.jpg

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Molecular Pathogenesis of Ischemic and Hemorrhagic Strokes: Background and Therapeutic Approaches.缺血性和出血性中风的分子发病机制：背景与治疗方法。
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