与袖状胃切除术相比,接受Roux-en-Y胃旁路手术的肥胖老年患者代谢获益增加。

Increased Metabolic Benefit for Obese, Elderly Patients Undergoing Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy.

作者信息

Gray Katherine D, Moore Maureen D, Bellorin Omar, Abelson Jonathan S, Dakin Gregory, Zarnegar Rasa, Pomp Alfons, Afaneh Cheguevara

机构信息

Department of Surgery, New York Presbyterian Hospital-Weill Cornell Medicine, 1300 York Ave. A1027, New York, NY, 10065, USA.

, 525 E 68th St, Box 294, New York, NY, 10021, USA.

出版信息

Obes Surg. 2018 Mar;28(3):636-642. doi: 10.1007/s11695-017-2904-2.

Abstract

PURPOSE

We sought to assess outcomes of laparoscopic sleeve gastrectomy (LSG) vs laparoscopic Roux-en-Y gastric bypass (LRYGB) in a cohort of morbidly obese, elderly patients.

MATERIALS AND METHODS

Retrospective review was conducted of all patients age 60 years or greater undergoing LSG or LRYGB at our institution between 2007 and 2014.

RESULTS

A total of 134 patients who underwent LSG (n = 65) or LRYGB (n = 69) were identified. Groups were similar with respect to age (64 years, range 60-75 years), BMI (44.0 ± 6.1), and ASA score (91% ≥ ASA 3). There were no differences in major post-operative complications (3, 4.7% LSG vs 4, 5.8% LRYGB, p = 0.75). Median follow-up was 39 months (IQR 14-64 months) with no patients lost to follow-up. Patients undergoing LRYGB had improvement in each of diabetes mellitus 2 (DM2), hypertension (HTN), hyperlipidemia (HL), and gastroesophageal reflux disease (GERD) as well as a significant decrease in insulin use (16/47, 34.0% pre-operatively vs 7/47, 15.2% post-operatively; p = 0.03). Patients undergoing LSG had improvement in DM2 and HTN but not in HL or GERD; there was no reduction in insulin dependence. Weight loss was not significantly different between groups; mean percent total weight loss at 36 months was 26.9 ± 9.0% in the LSG group and 23.9 ± 9.3% in the LRYGB group, p = 0.24.

CONCLUSIONS

Both LSG and RYGB can be safely performed on morbidly obese, elderly adults. At intermediate follow-up, there is an increased metabolic benefit for elderly patients undergoing LRYGB over LSG.

摘要

目的

我们试图评估在一组病态肥胖的老年患者中,腹腔镜袖状胃切除术(LSG)与腹腔镜Roux-en-Y胃旁路术(LRYGB)的治疗效果。

材料与方法

对2007年至2014年间在我院接受LSG或LRYGB手术的所有60岁及以上患者进行回顾性研究。

结果

共确定了134例行LSG(n = 65)或LRYGB(n = 69)的患者。两组在年龄(64岁,范围60 - 75岁)、体重指数(BMI,44.0 ± 6.1)和美国麻醉医师协会(ASA)评分(91%≥ASA 3级)方面相似。术后主要并发症无差异(LSG组3例,4.7%;LRYGB组4例,5.8%;p = 0.75)。中位随访时间为39个月(四分位间距14 - 64个月),无失访患者。接受LRYGB手术的患者在2型糖尿病(DM2)、高血压(HTN)、高脂血症(HL)和胃食管反流病(GERD)方面均有改善,胰岛素使用量显著减少(术前16/47,34.0%;术后7/47,15.2%;p = 0.03)。接受LSG手术的患者DM2和HTN有所改善,但HL和GERD无改善;胰岛素依赖无减少。两组间体重减轻无显著差异;LSG组36个月时平均总体重减轻百分比为26.9 ± 9.0%,LRYGB组为23.9 ± 9.3%,p = 0.24。

结论

LSG和RYGB均可安全地应用于病态肥胖的老年成年人。在中期随访中,老年患者接受LRYGB比LSG有更大的代谢益处。

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