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小鼠和人类的表观遗传衰老时钟。

Epigenetic aging clocks in mice and men.

作者信息

Wagner Wolfgang

机构信息

Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, University Hospital of the RWTH Aachen, 52074, Aachen, Germany.

Institute for Biomedical Engineering - Cell Biology, University Hospital of the RWTH Aachen, 52074, Aachen, Germany.

出版信息

Genome Biol. 2017 Jun 14;18(1):107. doi: 10.1186/s13059-017-1245-8.

DOI:10.1186/s13059-017-1245-8
PMID:28615041
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5470213/
Abstract

Epigenetic clocks provide powerful tools to evaluate nutritional, hormonal, and genetic effects on aging. What can we learn from differences between species in how these clocks tick?Please see related Research articles: http://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1203-5 , http://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1186-2 , http://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1187-1 and http://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1185-3.

摘要

表观遗传时钟为评估营养、激素和基因对衰老的影响提供了有力工具。从这些时钟在不同物种间运行方式的差异中我们能学到什么呢？请参阅相关研究文章：http://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1203-5 ，http://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1186-2 ，http://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1187-1 以及http://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1185-3 。

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