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哺乳动物听觉的频率敏感性源于内耳的基本非线性物理模型。

Frequency sensitivity in mammalian hearing from a fundamental nonlinear physics model of the inner ear.

机构信息

Institute of Neuroinformatics and Institute of Computational Science, University and ETH Zürich Irchel Campus, Winterthurerstr. 190, 8057, Zürich, Switzerland.

出版信息

Sci Rep. 2017 Aug 30;7(1):9931. doi: 10.1038/s41598-017-09854-2.

DOI:10.1038/s41598-017-09854-2
PMID:28855554
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5577103/
Abstract

A dominant view holds that the outer and middle ear are the determining factors for the frequency dependence of mammalian hearing sensitivity, but this view has been challenged. In the ensuing debate, there has been a missing element regarding in what sense and to what degree the biophysics of the inner ear might contribute to this frequency dependence. Here, we show that a simple model of the inner ear based on fundamental physical principles, reproduces, alone, the experimentally observed frequency dependence of the hearing threshold. This provides direct cochlea modeling support of the possibility that the inner ear could have a substantial role in determining the frequency dependence of mammalian hearing.

摘要

一种主流观点认为,哺乳动物听力灵敏度的频率依赖性取决于外耳和中耳,但这一观点受到了挑战。在随后的争论中,人们忽略了一个问题,即内耳的生物物理学在何种意义上以及在何种程度上可能对这种频率依赖性有贡献。在这里,我们展示了一个基于基本物理原理的内耳简单模型,它单独再现了实验观测到的听力阈值的频率依赖性。这为内耳在决定哺乳动物听力的频率依赖性方面可能具有重要作用的可能性提供了直接的耳蜗建模支持。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b01/5577103/b23e1618c193/41598_2017_9854_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b01/5577103/1cf874673fe4/41598_2017_9854_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b01/5577103/2ea3f1da73ea/41598_2017_9854_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b01/5577103/41d51da02e0f/41598_2017_9854_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b01/5577103/3ba78eab7c4d/41598_2017_9854_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b01/5577103/b23e1618c193/41598_2017_9854_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b01/5577103/1cf874673fe4/41598_2017_9854_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b01/5577103/2ea3f1da73ea/41598_2017_9854_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b01/5577103/41d51da02e0f/41598_2017_9854_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b01/5577103/3ba78eab7c4d/41598_2017_9854_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b01/5577103/b23e1618c193/41598_2017_9854_Fig5_HTML.jpg

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本文引用的文献

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Contribution of active hair-bundle motility to nonlinear amplification in the mammalian cochlea.主动毛束运动对哺乳动物耳蜗非线性放大的贡献。
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