Blott M, Greenough A, Nicolaides K H, Moscoso G, Gibb D, Campbell S
Lancet. 1987 Jul 18;2(8551):129-31. doi: 10.1016/s0140-6736(87)92332-4.
In 11 pregnancies complicated by oligohydramnios due to spontaneous rupture of the membranes in the second trimester of pregnancy fetal breathing movements were assessed regularly by ultrasonographic examinations. In the 6 cases in which fetal breathing movements were detected the babies were liveborn and there was no evidence of pulmonary hypoplasia or the other non-renal features of Potter's syndrome. In the other 5 cases there were no fetal breathing movements. 1 pregnancy was terminated electively, and 1 ended in an intrauterine death; the remaining 3 infants died in the neonatal period. All 5 cases showed necropsy evidence of pulmonary hypoplasia. These findings indicate that premature and prolonged rupture of membranes in the second trimester of pregnancy does not uniformly result in a poor prognosis. They suggest that fetal breathing movements could be used as a predictor of favourable neonatal outcome.
在11例因妊娠中期胎膜自然破裂而并发羊水过少的妊娠中，通过超声检查定期评估胎儿呼吸运动。在检测到胎儿呼吸运动的6例中，婴儿存活，且没有肺发育不全或波特综合征其他非肾脏特征的证据。在另外5例中未检测到胎儿呼吸运动。1例妊娠被选择性终止，1例以宫内死亡告终；其余3例婴儿在新生儿期死亡。所有5例尸检均显示有肺发育不全的证据。这些发现表明，妊娠中期胎膜过早和长期破裂并非都会导致不良预后。它们提示胎儿呼吸运动可作为新生儿良好结局的预测指标。
