Osaka University of Pharmaceutical Sciences , 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.
Rigaku Corporation, 3-9-12, Matsubara-cho, Akishima-shi, Tokyo 196-8666, Japan.
J Org Chem. 2017 Oct 6;82(19):10611-10616. doi: 10.1021/acs.joc.7b01259. Epub 2017 Sep 20.
Two novel 11(9 → 7)-abeo-ergostane-type steroids, named pleurocins A (1) and B (2), a 13,14-seco-13,14-epoxy ergostane, named eringiacetal B (3), and an ergostane steroid (4) were isolated from the fruiting bodies of Pleurotus eryngii (Pleurotaceae). Their structures were determined by spectroscopic data and X-ray crystallography. A possible biogenesis pathway for 1-3 was also described. Compounds 1-3 exhibited inhibitory activities against NO production with almost no cytotoxicity at concentrations lower than 30 μM.
两种新型的 11(9 → 7)-abeo-ergostane 型甾体化合物，命名为 pleurocins A（1）和 B（2），一种 13,14-secocyclo-13,14-epoxy ergostane，命名为 eringiacetal B（3），以及一种 ergostane 甾体化合物（4），从杏鲍菇（Pleurotaceae）的子实体中分离得到。通过光谱数据和 X 射线晶体学确定了它们的结构。还描述了 1-3 的可能生物合成途径。化合物 1-3 在低于 30 μM 的浓度下表现出对 NO 产生的抑制活性，几乎没有细胞毒性。
