Korzeniewski Steven J, Joseph Robert M, Kim So Hyun, Allred Elizabeth N, OʼShea T Michael, Leviton Alan, Kuban Karl C K
*Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI; †Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI; ‡Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA; §Department of Psychiatry, Weill Cornell Medical College, New York, NY; ‖Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA; ¶Department of Pediatrics, University of North Carolina, Raleigh, NC; **Department of Pediatrics, Boston Medical Center, Boston University, Boston, MA.
J Dev Behav Pediatr. 2017 Nov/Dec;38(9):697-705. doi: 10.1097/DBP.0000000000000485.
To evaluate the correlates of a clinically significant high score on the Social Responsiveness Scale (SRS) in 10-year-old children who were born extremely preterm and who did not meet criteria for autism spectrum disorder (ASD).
After excluding 61 participants diagnosed with ASD, we grouped children by IQ < or ≥85 and then compared the prevalence of neurocognitive and other deficits between those who had SRS total and component scores ≥65 and their peers who had lower scores.
Among children who had IQ ≥ 85, the prevalence of SRS total scores ≥65 was 16% (n = 103/628), and among children who had IQ < 85, it was 27% (n = 40/148), higher than the 4% prevalence expected based on normative population data. Among children who had IQ ≥ 85, those who had high SRS scores more often than their peers had deficits in attention and executive function, and language and communication, and they were more often rated by their parents and teachers as having behavioral (e.g., attention-deficit hyperactivity disorder [ADHD]) and emotional (e.g., anxiety and depression) problems.
Social Responsiveness Scale-defined social impairment was much more common in our cohort of 10-year-old children born extremely preterm than was expected based on general population norms. High SRS scores were characteristic of children who had intellectual, neurocognitive, language, and communication limitations, as well as deficits in behavior and emotion regulation.
评估出生时为极早产儿且不符合自闭症谱系障碍（ASD）标准的10岁儿童在社会反应量表（SRS）上临床显著高分的相关因素。
在排除61名被诊断为ASD的参与者后，我们根据智商（IQ）<或≥85对儿童进行分组，然后比较SRS总分和分量表得分≥65的儿童与得分较低的同龄人之间神经认知和其他缺陷的患病率。
在IQ≥85的儿童中，SRS总分≥65的患病率为16%（n = 103/628），在IQ<85的儿童中，患病率为27%（n = 40/148），高于基于正常人群数据预期的4%患病率。在IQ≥85的儿童中，SRS得分高的儿童比同龄人更常出现注意力和执行功能、语言和沟通方面的缺陷，并且他们的父母和老师更常将其评定为有行为问题（如注意力缺陷多动障碍[ADHD]）和情绪问题（如焦虑和抑郁）。
在我们这个出生时为极早产儿的10岁儿童队列中，社会反应量表定义的社会功能损害比基于一般人群规范预期的更为常见。SRS高分是那些存在智力、神经认知、语言和沟通限制以及行为和情绪调节缺陷儿童的特征。
