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腰椎椎间融合手术中意外硬脊膜切开的危险因素及处理

Risk Factors and Management of Incidental Durotomy in Lumbar Interbody Fusion Surgery.

作者信息

Enders Frederik, Ackemann Amelie, Müller Simon, Kiening Karl, Orakcioglu Berk

机构信息

Department of Neurosurgery, University Hospital Heidelberg, Heidelberg.

TTI GmbH-MUON-STAT, University Stuttgart, Stuttgart, Germany.

出版信息

Clin Spine Surg. 2018 Apr;31(3):127-131. doi: 10.1097/BSD.0000000000000572.

Abstract

STUDY DESIGN

This is a retrospective study analysis.

OBJECTIVE

In this retrospective study we evaluated risk factors for incidental durotomy and its impact on the postoperative course.

SUMMARY OF BACKGROUND DATA

Lumbar interbody fusion (LIF) is increasingly applied for the treatment of degenerative instability. A known complication is incidental durotomy.

MATERIALS AND METHODS

A cohort of 541 patients who underwent primary LIF surgery between 2005 and 2015 was analyzed. Previous lumbar surgery, age, surgeon's experience, intraoperative use of a microscope, and the number of operated levels were assessed and the risk for incidental durotomy was estimated using the Log-likelihood test and Wald test, respectively. The association of incidental durotomy and outcome parameters was analyzed using the quantile regression model.

RESULTS

In 77 (14.2%) patients intraoperative cerebrospinal fluid (CSF) fistula was observed. Previous lumbar surgery (P<0.001), number of operated levels (P=0.03), and surgeon's experience (P=0.01) were significantly associated with incidental durotomy. Incidental durotomy was significantly associated with a prolonged bed rest (P<0.001), hospital stay (P=0.041), and an increased use of postoperative antibiotics (P<0.001). Eleven of 77 patients with incidental durotomy (14.3%) developed postoperative CSF fistula of whom 10 (91%) needed revision surgery for dural repair.

CONCLUSIONS

We could identify important risk factors for incidental durotomy in LIF surgery. In patients who had undergone previous lumbar surgery and those with multilevel disease particular precaution is required. Furthermore, we were able to verify the morbidity associated with CSF fistula as shown by increased immobilization and follow-up surgeries for postoperative CSF fistula which emphasizes the importance to develop strategies to minimize the risk for incidental durotomy.

摘要

研究设计

这是一项回顾性研究分析。

目的

在这项回顾性研究中,我们评估了意外硬脊膜切开术的危险因素及其对术后病程的影响。

背景数据总结

腰椎椎间融合术(LIF)越来越多地应用于治疗退行性不稳定。一个已知的并发症是意外硬脊膜切开术。

材料与方法

分析了2005年至2015年间接受初次LIF手术的541例患者队列。评估既往腰椎手术史、年龄、外科医生经验、术中显微镜使用情况以及手术节段数量,并分别使用对数似然检验和 Wald 检验估计意外硬脊膜切开术的风险。使用分位数回归模型分析意外硬脊膜切开术与结局参数之间的关联。

结果

77例(14.2%)患者术中观察到脑脊液(CSF)瘘。既往腰椎手术史(P<0.001)、手术节段数量(P=0.03)和外科医生经验(P=0.01)与意外硬脊膜切开术显著相关。意外硬脊膜切开术与卧床休息时间延长(P<0.001)、住院时间延长(P=0.041)以及术后抗生素使用增加(P<0.001)显著相关。77例意外硬脊膜切开术患者中有11例(14.3%)发生术后CSF瘘,其中10例(91%)需要进行硬膜修复的翻修手术。

结论

我们能够确定LIF手术中意外硬脊膜切开术的重要危险因素。对于既往接受过腰椎手术的患者和患有多节段疾病的患者,需要特别谨慎。此外,我们能够证实与CSF瘘相关的发病率,如术后CSF瘘导致的固定时间增加和翻修手术,这强调了制定策略以尽量降低意外硬脊膜切开术风险的重要性。

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