Department of Plant and Microbial Biology, University of California, Berkeley, USA; Innovative Genomics Institute, University of California, Berkeley, USA.
Department of Plant and Microbial Biology, University of California, Berkeley, USA; Innovative Genomics Institute, University of California, Berkeley, USA.
Curr Opin Plant Biol. 2020 Dec;58:60-68. doi: 10.1016/j.pbi.2020.10.006. Epub 2020 Nov 17.
Nuclear pore complexes (NPC) are highly conserved mega protein complexes that penetrate the double-layered nuclear membrane and form channels to allow bi-directional transport of macromolecules between the nucleus and the cytosol. Non-passive nucleocytoplasmic transport also requires nuclear transport receptors (NTR), which bind cargo molecules and shuttle them across the NPC. The NPC and NTRs constitute two fundamental layers of regulatory mechanisms that together determine the selective nuclear translocation of signal molecules and play essential roles in activating the precise response of a cell to environmental stimuli. Here we discuss recent findings in the NPC made by advanced structural biology approaches, and dissect distinct functions of different NPC components and NTRs in plants' responses to various biotic and abiotic stresses.
核孔复合体（NPC）是高度保守的巨型蛋白复合物，它们穿透双层核膜并形成通道，允许大分子在核和细胞质之间进行双向运输。非被动核质运输还需要核转运受体（NTR），它结合货物分子并将它们穿梭过 NPC。NPC 和 NTR 构成了两个基本的调节机制层，共同决定信号分子的选择性核转位，并在激活细胞对环境刺激的精确反应中发挥重要作用。在这里，我们讨论了利用先进的结构生物学方法在 NPC 方面取得的最新发现，并剖析了不同 NPC 成分和 NTR 在植物对各种生物和非生物胁迫的反应中的不同功能。
