Zhang Xianming, Wang Xiaohui, Ren Ning, Kuang Zhonghua, Deng Xinhan, Fu Xin, Wu San, Sang Ziru, Hu Zhanli, Liang Dong, Liu Xin, Zheng Hairong, Yang Yongfeng
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, People's Republic of China. School of Nuclear Science and Technology, Lanzhou University, Lanzhou, People's Republic of China.
Phys Med Biol. 2017 Sep 21;62(19):7889-7904. doi: 10.1088/1361-6560/aa898a.
A depth encoding PET detector module using semi-monolithic scintillation crystal single-ended readout by a SiPM array was built and its performance was measured. The semi-monolithic scintillator detector consists of 11 polished LYSO slices measuring 1 × 11.6 × 10 mm. The slices are glued together with enhanced specular reflector (ESR) in between and outside of the slices. The bottom surface of the slices is coupled to a 4 × 4 SiPM array with a 1 mm light guide and silicon grease between them. No reflector is used on the top surface and two sides of the slices to reduce the scintillation photon reflection. The signals of the 4 × 4 SiPM array are grouped along rows and columns separately into eight signals. Four SiPM column signals are used to identify the slices according to the center of the gravity of the scintillation photon distribution in the pixelated direction. Four SiPM row signals are used to estimate the y (monolithic direction) and z (depth of interaction) positions according to the center of the gravity and the width of the scintillation photon distribution in the monolithic direction, respectively. The detector was measured with 1 mm sampling interval in both the y and z directions with electronic collimation by using a 0.25 mm diameter Na point source and a 1 × 1 × 20 mm LYSO crystal detector. An average slice based energy resolution of 14.9% was obtained. All slices of 1 mm thick were clearly resolved and a detector with even thinner slices could be used. The y positions calculated with the center of gravity method are different for interactions happening at the same y, but different z positions due to depth dependent edge effects. The least-square minimization and the maximum likelihood positioning algorithms were developed and both methods improved the spatial resolution at the edges of the detector as compared with the center of gravity method. A mean absolute error (MAE) which is defined as the probability-weighted mean of the absolute value of the positioning error is used to evaluate the spatial resolution. An average MAE spatial resolution of ~1.15 mm was obtained in both y and z directions without rejection of the multiple scattering events. The average MAE spatial resolution was ~0.7 mm in both y and z directions after the multiple scattering events were rejected. The timing resolution of the detector is 575 ps. In the next step, long rectangle detector will be built to reduce edge effects and improve the spatial resolution of the semi-monolithic detector. Thick detector up to 20 mm will be explored and the positioning algorithms will be further optimized.
构建了一种采用半单片闪烁晶体并通过硅光电倍增管(SiPM)阵列进行单端读出的深度编码正电子发射断层扫描(PET)探测器模块,并对其性能进行了测量。该半单片闪烁体探测器由11个经过抛光的硅酸钇镥(LYSO)切片组成,尺寸为1×11.6×10毫米。这些切片在其内部和外部通过增强型镜面反射器(ESR)粘合在一起。切片的底面通过1毫米的光导和其间的硅脂与一个4×4的SiPM阵列耦合。切片的顶面和两侧不使用反射器,以减少闪烁光子的反射。4×4 SiPM阵列的信号分别按行和列分组为八个信号。四个SiPM列信号用于根据像素化方向上闪烁光子分布的重心来识别切片。四个SiPM行信号分别用于根据重心以及单片方向上闪烁光子分布的宽度来估计y(单片方向)和z(相互作用深度)位置。使用直径为0.25毫米的钠点源和一个1×1×20毫米的LYSO晶体探测器,通过电子准直在y和z方向上以1毫米的采样间隔对探测器进行测量。获得了基于切片平均能量分辨率为14.9%。所有1毫米厚的切片都能清晰分辨,并且可以使用更薄切片的探测器。对于在相同y位置但不同z位置发生的相互作用,用重心法计算出的y位置不同,这是由于与深度相关的边缘效应。开发了最小二乘最小化和最大似然定位算法,与重心法相比,这两种方法都提高了探测器边缘处的空间分辨率。使用定义为定位误差绝对值的概率加权平均值的平均绝对误差(MAE)来评估空间分辨率。在不排除多次散射事件的情况下,在y和z方向上均获得了约1.15毫米的平均MAE空间分辨率。在排除多次散射事件后,y和z方向上的平均MAE空间分辨率均约为0.7毫米。探测器的时间分辨率为575皮秒。下一步,将构建长矩形探测器以减少边缘效应并提高半单片探测器的空间分辨率。将探索厚度达20毫米的厚探测器,并进一步优化定位算法。