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芽囊原虫属加剧结肠癌发生

Exacerbation of colon carcinogenesis by Blastocystis sp.

作者信息

Kumarasamy Vinoth, Kuppusamy Umah Rani, Jayalakshmi Pailoor, Samudi Chandramathi, Ragavan Nanthiney Devi, Kumar Suresh

机构信息

Department of Microbiology, Faculty of Medicine, MAHSA University, Bandar Saujana Putra, Shah Alam, Malaysia.

Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

出版信息

PLoS One. 2017 Aug 31;12(8):e0183097. doi: 10.1371/journal.pone.0183097. eCollection 2017.

DOI:10.1371/journal.pone.0183097
PMID:28859095
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5578604/
Abstract

Colorectal cancer (CRC) is one the most commonly diagnosed cancers worldwide and the number is increasing every year. Despite advances in screening programs, CRC remains as the second leading cause of cancer deaths in the United States. Oxidative stress plays an important role in the molecular mechanisms of colorectal cancer (CRC) and has been shown to be associated with Blastocystis sp., a common intestinal microorganism. In the present study, we aimed to identify a role for Blastocystis sp. in exacerbating carcinogenesis using in vivo rat model. Methylene blue staining was used to identify colonic aberrant crypt foci (ACF) and adenomas formation in infected rats whilst elevation of oxidative stress biomarker levels in the urine and serum samples were evaluated using biochemical assays. Histological changes of the intestinal mucosa were observed and a significant number of ACF was found in Blastocystis sp. infected AOM-rats compared to the AOM-controls. High levels of urinary oxidative indices including advanced oxidative protein products (AOPP) and hydrogen peroxide were observed in Blastocystis sp. infected AOM-rats compared to the uninfected AOM-rats. Our study provides evidence that Blastocystis sp. has a significant role in enhancing AOM-induced carcinogenesis by resulting damage to the intestinal epithelium and promoting oxidative damage in Blastocystis sp. infected rats.

摘要

结直肠癌（CRC）是全球最常被诊断出的癌症之一，且其数量逐年增加。尽管筛查项目有所进展，但CRC在美国仍是癌症死亡的第二大主要原因。氧化应激在结直肠癌（CRC）的分子机制中起重要作用，并且已被证明与一种常见的肠道微生物——芽囊原虫属有关。在本研究中，我们旨在利用体内大鼠模型确定芽囊原虫属在加剧致癌作用中的作用。使用亚甲蓝染色来识别感染大鼠的结肠异常隐窝灶（ACF）和腺瘤形成，同时使用生化测定法评估尿液和血清样本中氧化应激生物标志物水平的升高。观察肠道黏膜的组织学变化，与AOM对照组相比，在感染芽囊原虫属的AOM大鼠中发现了大量的ACF。与未感染的AOM大鼠相比，在感染芽囊原虫属的AOM大鼠中观察到高水平的尿液氧化指标，包括晚期氧化蛋白产物（AOPP）和过氧化氢。我们的研究提供了证据，表明芽囊原虫属通过对肠道上皮造成损伤并促进感染芽囊原虫属的大鼠的氧化损伤，在增强AOM诱导的致癌作用中起重要作用。

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