Tocci Stefania, Das Soumita, Sayed Ibrahim M
Department of Biomedical & Nutritional Sciences, Zuckerberg College of Health Sciences, University of Massachusetts Lowell, Lowell, MA 01854, USA.
Microorganisms. 2024 Sep 22;12(9):1924. doi: 10.3390/microorganisms12091924.
is an anaerobic parasite that colonizes the intestinal tract of humans and animals. When it was first discovered, was considered to be a normal flora with beneficial effects on human health, such as maintaining gut hemostasis and improving intestinal barrier integrity. Later, with increasing research on , reports showed that sp. is associated with gastrointestinal disorders, colorectal cancer (CRC), and neurological disorders. The association between sp. and CRC has been confirmed in several countries. sp. can mediate CRC via similar mechanisms to CRC-associated bacteria, including infection-mediated inflammation, increased oxidative stress, induced gut dysbiosis, and damage to intestinal integrity, leading to a leaky gut. IL-8 is the main inflammatory cytokine released from epithelial cells and can promote CRC development. The causal association of sp. with other diseases needs further investigation. In this review, we have provided an update on sp. and summarized the debate about the beneficial and harmful effects of this parasite. We have also highlighted the possible mechanisms of -mediated CRC.
是一种厌氧寄生虫，寄生于人和动物的肠道。首次发现时，被认为是对人类健康有益的正常菌群，比如维持肠道止血和改善肠道屏障完整性。后来，随着对其研究的增加，报告显示该菌与胃肠道疾病、结直肠癌（CRC）和神经系统疾病有关。在几个国家已证实该菌与结直肠癌之间存在关联。该菌可通过与结直肠癌相关细菌类似的机制介导结直肠癌，包括感染介导的炎症、氧化应激增加、肠道微生物群失调以及肠道完整性受损，导致肠道渗漏。白细胞介素-8（IL-8）是上皮细胞释放的主要炎症细胞因子，可促进结直肠癌的发展。该菌与其他疾病的因果关系需要进一步研究。在本综述中，我们提供了关于该菌的最新信息，并总结了关于这种寄生虫有益和有害作用的争论。我们还强调了该菌介导结直肠癌的可能机制。
