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某些物种在胃肠道疾病和自身免疫性疾病病因学中的作用。 (注:原文本中“spp.”表述有误,推测可能是“species”,这里按照纠正后的理解翻译。)

The Role of spp. in the Etiology of Gastrointestinal and Autoimmune Diseases.

作者信息

Pawelec-Pęciak Oliwia, Łanocha-Arendarczyk Natalia, Grzeszczak Konrad, Kosik-Bogacka Danuta

机构信息

Department of Biology, Parasitology and Pharmaceutical Botany, Pomeranian Medical University in Szczecin, Powstanców Wielkopolskich 72, 70-111 Szczecin, Poland.

Department of Medical Analytics, Pomeranian Medical University in Szczecin, Powstanców Wielkopolskich 72, 70-111 Szczecin, Poland.

出版信息

Pathogens. 2025 Mar 25;14(4):313. doi: 10.3390/pathogens14040313.

Abstract

spp. has been linked to gastrointestinal symptoms, yet its pathogenicity remains uncertain. In addition, the roles of virulence factors, pathogenic potential, and host-specific traits associated with symptomatic infections are still not well understood. The growing number of immunocompromised patients has contributed to an increasing prevalence of spp. infections, which may be implicated in the development of various inflammatory diseases, including irritable bowel syndrome (IBS), colorectal cancer, and autoimmune disorders such as Hashimoto's disease and ulcerative colitis. However, the presence of nonspecific symptoms often complicates diagnosis. This study aimed to present current data on the impact of spp. on the development and progression of gastrointestinal and autoimmune diseases, as well as to explore potential treatment options for spp. infections. A literature review was conducted to analyze the role of spp. in the pathogenesis of specific diseases and to investigate potential mechanisms of its interaction with the host organism. Advances in diagnostic techniques, particularly PCR, allow not only for the detection of spp. but also for the identification of specific subtypes, improving treatment precision. Beyond conventional therapies like metronidazole, there is a growing emphasis on alternative treatments, including the use of medicinal plants and probiotics.

摘要

某物种已被发现与胃肠道症状有关,但其致病性仍不明确。此外,与有症状感染相关的毒力因子、致病潜力和宿主特异性特征的作用仍未得到充分了解。免疫功能低下患者数量的增加导致某物种感染的患病率上升,这可能与各种炎症性疾病的发展有关,包括肠易激综合征(IBS)、结直肠癌以及自身免疫性疾病,如桥本氏病和溃疡性结肠炎。然而,非特异性症状的存在常常使诊断复杂化。本研究旨在提供有关某物种对胃肠道和自身免疫性疾病的发生和发展影响的当前数据,并探索某物种感染的潜在治疗选择。进行了一项文献综述,以分析某物种在特定疾病发病机制中的作用,并研究其与宿主生物体相互作用的潜在机制。诊断技术的进步,特别是聚合酶链反应(PCR),不仅能够检测某物种,还能识别特定亚型,提高治疗的精准度。除了甲硝唑等传统疗法外,人们越来越重视替代疗法,包括使用药用植物和益生菌。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23b5/12030515/06e83eafd08e/pathogens-14-00313-g001.jpg

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